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Gene Review: 

Pex12  -  peroxisomal biogenesis factor 12

Rattus norvegicus

Synonyms: PAF-3, Paf3, Peroxin-12, Peroxisome assembly factor 3, Peroxisome assembly protein 12
 
 
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High impact information on Pex12

  • Although its sequence similarity to yeast Pex12 proteins was limited, PEX12 shared the same subcellular distribution as yeast Pex12p and localized to the peroxisome membrane [1].
  • We identified a putative human orthologue of ScPEX12 by screening the database of expressed sequence tags for cDNAs capable of encoding a protein similar to yeast Pex12p [1].
  • Pex12p was shown by expression of bona fide as well as epitope-tagged Pex12p to expose both N- and C-terminal regions to the cytosol [2].
  • After solubilization of rat liver peroxisomes with the mild detergent digitonin, comigration of Pex5p, Pex14p, and a fraction of Pex12p was observed upon native electrophoresis and sucrose gradient sedimentation [3].

References

  1. Isolation of the human PEX12 gene, mutated in group 3 of the peroxisome biogenesis disorders. Chang, C.C., Lee, W.H., Moser, H., Valle, D., Gould, S.J. Nat. Genet. (1997) [Pubmed]
  2. PEX12, the pathogenic gene of group III Zellweger syndrome: cDNA cloning by functional complementation on a CHO cell mutant, patient analysis, and characterization of PEX12p. Okumoto, K., Shimozawa, N., Kawai, A., Tamura, S., Tsukamoto, T., Osumi, T., Moser, H., Wanders, R.J., Suzuki, Y., Kondo, N., Fujiki, Y. Mol. Cell. Biol. (1998) [Pubmed]
  3. Characterization of the mammalian peroxisomal import machinery: Pex2p, Pex5p, Pex12p, and Pex14p are subunits of the same protein assembly. Reguenga, C., Oliveira, M.E., Gouveia, A.M., Sá-Miranda, C., Azevedo, J.E. J. Biol. Chem. (2001) [Pubmed]
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