The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Pex12  -  peroxisomal biogenesis factor 12

Rattus norvegicus

Synonyms: PAF-3, Paf3, Peroxin-12, Peroxisome assembly factor 3, Peroxisome assembly protein 12
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on Pex12

  • Although its sequence similarity to yeast Pex12 proteins was limited, PEX12 shared the same subcellular distribution as yeast Pex12p and localized to the peroxisome membrane [1].
  • We identified a putative human orthologue of ScPEX12 by screening the database of expressed sequence tags for cDNAs capable of encoding a protein similar to yeast Pex12p [1].
  • Pex12p was shown by expression of bona fide as well as epitope-tagged Pex12p to expose both N- and C-terminal regions to the cytosol [2].
  • After solubilization of rat liver peroxisomes with the mild detergent digitonin, comigration of Pex5p, Pex14p, and a fraction of Pex12p was observed upon native electrophoresis and sucrose gradient sedimentation [3].


  1. Isolation of the human PEX12 gene, mutated in group 3 of the peroxisome biogenesis disorders. Chang, C.C., Lee, W.H., Moser, H., Valle, D., Gould, S.J. Nat. Genet. (1997) [Pubmed]
  2. PEX12, the pathogenic gene of group III Zellweger syndrome: cDNA cloning by functional complementation on a CHO cell mutant, patient analysis, and characterization of PEX12p. Okumoto, K., Shimozawa, N., Kawai, A., Tamura, S., Tsukamoto, T., Osumi, T., Moser, H., Wanders, R.J., Suzuki, Y., Kondo, N., Fujiki, Y. Mol. Cell. Biol. (1998) [Pubmed]
  3. Characterization of the mammalian peroxisomal import machinery: Pex2p, Pex5p, Pex12p, and Pex14p are subunits of the same protein assembly. Reguenga, C., Oliveira, M.E., Gouveia, A.M., Sá-Miranda, C., Azevedo, J.E. J. Biol. Chem. (2001) [Pubmed]
WikiGenes - Universities