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Gene Review:

ARAP1 - ArfGAP with RhoGAP domain, ankyrin repeat...

Homo sapiens

Synonyms: Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1, CENTD2, Centaurin-delta-2, Cnt-d2, KIAA0782

Guo, D.F. et al., Miura, K. et al.

Guo, Chenier, Tardif, Orlov, Inagami,

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High impact information on CENTD2

The Rho GAP activity mediated cell rounding and loss of stress fibers when ARAP1 was overexpressed [1].
Immunocytochemical analysis revealed co-localization of recycled AT(1A) and ARAP1 in the plasma membrane 45 min after the initial exposure to Ang II [2].

Anatomical context of CENTD2

In the present study, we report the isolation of a novel protein, ARAP1, which promotes recycling of AT(1A) to the plasma membrane in HEK-293 cells [2].

Analytical, diagnostic and therapeutic context of CENTD2

A complex of ARAP1 and AT(1A) was observed by immunoprecipitation and Western blotting in HEK-293 cells [2].

References

ARAP1: a point of convergence for Arf and Rho signaling. Miura, K., Jacques, K.M., Stauffer, S., Kubosaki, A., Zhu, K., Hirsch, D.S., Resau, J., Zheng, Y., Randazzo, P.A. Mol. Cell (2002) [Pubmed]
Type 1 angiotensin II receptor-associated protein ARAP1 binds and recycles the receptor to the plasma membrane. Guo, D.F., Chenier, I., Tardif, V., Orlov, S.N., Inagami, T. Biochem. Biophys. Res. Commun. (2003) [Pubmed]

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