Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

MRGPRX2 - MAS-related GPR, member X2

Homo sapiens

Synonyms: MGRG3, MRGX2, Mas-related G-protein coupled receptor member X2

Yang, S. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on MRGPRX2

Adaptive evolution of MRGX2, a human sensory neuron specific gene involved in nociception [1].
MRGX2, a G-protein-coupled receptor, is specifically expressed in the sensory neurons of the human peripheral nervous system and involved in nociception [1].
The reconstructed secondary structure of the human MRGX2 revealed that three of the four human-specific amino acid substitutions were located in the extra-cellular domains [1].
The patterns of DNA sequence polymorphisms in human populations showed an excess of derived substitutions, which against the expectation of neutral evolution, implying that the adaptive evolution of MRGX2 in humans was a relatively recent event [1].

References

Adaptive evolution of MRGX2, a human sensory neuron specific gene involved in nociception. Yang, S., Liu, Y., Lin, A.A., Cavalli-Sforza, L.L., Zhao, Z., Su, B. Gene (2005) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

MRGPRX2	Bos taurus
MRGPRX2	Canis lupus familiaris
MRGPRX2	Macaca mulatta
Mrgprb1	Mus musculus
Mrgprx2	Mus musculus
MRGPRX2	Pan troglodytes
Mrgprx2	Rattus norvegicus

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

Editor

Share