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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Ptpn23  -  protein tyrosine phosphatase, non-receptor...

Rattus norvegicus

Synonyms: HD-PTP, His domain-containing protein tyrosine phosphatase, PTP-TD14, Protein tyrosine phosphatase TD14, Ptp-Td14, ...
 
 
 
 
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High impact information on Ptpn23

  • This inhibitory activity is localized to the C-terminal PTPase homology domain, since no inhibition of Ha-ras-mediated focus formation was observed with a PTP-TD14 mutant, in which the putative catalytic activity was presumably inactivated by a point mutation [1].
  • These findings indicate that PTP-TD14 encodes a novel protein that may be critically involved in regulating Ha-ras-dependent cell growth [1].
 

Analytical, diagnostic and therapeutic context of Ptpn23

  • By Northern blot analysis, PTP-TD14 is expressed as a 5.3-kilobase pair transcript, not only in neonatal heart but also in many adult rat tissues [1].

References

  1. A novel putative protein-tyrosine phosphatase contains a BRO1-like domain and suppresses Ha-ras-mediated transformation. Cao, L., Zhang, L., Ruiz-Lozano, P., Yang, Q., Chien, K.R., Graham, R.M., Zhou, M. J. Biol. Chem. (1998) [Pubmed]
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