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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

TRIM6  -  tripartite motif containing 6

Homo sapiens

Synonyms: RING finger protein 89, RNF89, Tripartite motif-containing protein 6
 
 
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Disease relevance of TRIM6

  • The RING, B-box 2, and CC domains of the paralogous TRIM6 and TRIM34 proteins functionally replaced the corresponding TRIM5alpha(rh) domains, allowing HIV-1 restriction [1].
 

High impact information on TRIM6

  • Here we investigated the abilities of domains from TRIM proteins (TRIM6, TRIM34, and TRIM21) that do not restrict HIV-1 infection to substitute for the domains of rhesus monkey TRIM5alpha (TRIM5alpha(rh)) [1].
  • Human TRIM5alpha gene is located on chromosomal position 11p15 in a cluster with other TRIM genes including TRIM6, 21, 22, and 34 [2].

References

  1. Functional replacement of the RING, B-box 2, and coiled-coil domains of tripartite motif 5alpha (TRIM5alpha) by heterologous TRIM domains. Li, X., Li, Y., Stremlau, M., Yuan, W., Song, B., Perron, M., Sodroski, J. J. Virol. (2006) [Pubmed]
  2. A retrovirus restriction factor TRIM5alpha is transcriptionally regulated by interferons. Asaoka, K., Ikeda, K., Hishinuma, T., Horie-Inoue, K., Takeda, S., Inoue, S. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
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