Gene Review:
TRIM5 - tripartite motif containing 5
Homo sapiens
Synonyms:
RING finger protein 88, RNF88, TRIM5alpha, Tripartite motif-containing protein 5
- Cyclophilin A is required for TRIM5{alpha}-mediated resistance to HIV-1 in Old World monkey cells. Berthoux, L., Sebastian, S., Sokolskaja, E., Luban, J. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Proteasome Inhibition Reveals that a Functional Preintegration Complex Intermediate Can Be Generated during Restriction by Diverse TRIM5 Proteins. Anderson, J.L., Campbell, E.M., Wu, X., Vandegraaff, N., Engelman, A., Hope, T.J. J. Virol. (2006)
- Cyclophilin A, TRIM5, and resistance to human immunodeficiency virus type 1 infection. Luban, J. J. Virol. (2007)
- Trim-cyclophilin A fusion proteins can restrict human immunodeficiency virus type 1 infection at two distinct phases in the viral life cycle. Yap, M.W., Dodding, M.P., Stoye, J.P. J. Virol. (2006)
- Structural and functional insights into the B30.2/SPRY domain. Woo, J.S., Imm, J.H., Min, C.K., Kim, K.J., Cha, S.S., Oh, B.H. EMBO J. (2006)
- Evolution of a cytoplasmic tripartite motif (TRIM) protein in cows that restricts retroviral infection. Si, Z., Vandegraaff, N., O'huigin, C., Song, B., Yuan, W., Xu, C., Perron, M., Li, X., Marasco, W.A., Engelman, A., Dean, M., Sodroski, J. Proc. Natl. Acad. Sci. U.S.A. (2006)
- Generation of HIV-1 derivatives that productively infect macaque monkey lymphoid cells. Kamada, K., Igarashi, T., Martin, M.A., Khamsri, B., Hatcho, K., Yamashita, T., Fujita, M., Uchiyama, T., Adachi, A. Proc. Natl. Acad. Sci. U.S.A. (2006)
- Proteasome inhibitors uncouple rhesus TRIM5alpha restriction of HIV-1 reverse transcription and infection. Wu, X., Anderson, J.L., Campbell, E.M., Joseph, A.M., Hope, T.J. Proc. Natl. Acad. Sci. U.S.A. (2006)
- Cyclophilin A Renders Human Immunodeficiency Virus Type 1 Sensitive to Old World Monkey but Not Human TRIM5{alpha} Antiviral Activity. Keckesova, Z., Ylinen, L.M., Towers, G.J. J. Virol. (2006)
- Removal of arginine 332 allows human TRIM5alpha to bind human immunodeficiency virus capsids and to restrict infection. Li, Y., Li, X., Stremlau, M., Lee, M., Sodroski, J. J. Virol. (2006)
- Cyclophilin interactions with incoming human immunodeficiency virus type 1 capsids with opposing effects on infectivity in human cells. Hatziioannou, T., Perez-Caballero, D., Cowan, S., Bieniasz, P.D. J. Virol. (2005)
- Cyclophilin, TRIM5, and innate immunity to HIV-1. Sokolskaja, E., Luban, J. Curr. Opin. Microbiol. (2006)
- Genetic association of the antiviral restriction factor TRIM5alpha with human immunodeficiency virus type 1 infection. Speelmon, E.C., Livingston-Rosanoff, D., Li, S.S., Vu, Q., Bui, J., Geraghty, D.E., Zhao, L.P., McElrath, M.J. J. Virol. (2006)
- Disruption of human TRIM5alpha antiviral activity by nonhuman primate orthologues. Berthoux, L., Sebastian, S., Sayah, D.M., Luban, J. J. Virol. (2005)
- Cyclophilin A and TRIM5alpha independently regulate human immunodeficiency virus type 1 infectivity in human cells. Sokolskaja, E., Berthoux, L., Luban, J. J. Virol. (2006)
- Trim5alpha protein restricts both HIV-1 and murine leukemia virus. Yap, M.W., Nisole, S., Lynch, C., Stoye, J.P. Proc. Natl. Acad. Sci. U.S.A. (2004)
- Arsenic counteracts human immunodeficiency virus type 1 restriction by various TRIM5 orthologues in a cell type-dependent manner. Sebastian, S., Sokolskaja, E., Luban, J. J. Virol. (2006)
- Trim5{alpha} Accelerates Degradation of Cytosolic Capsid Associated with Productive HIV-1 Entry. Chatterji, U., Bobardt, M.D., Gaskill, P., Sheeter, D., Fox, H., Gallay, P.A. J. Biol. Chem. (2006)
- Restriction of human immunodeficiency virus type 1 by TRIM-CypA occurs with rapid kinetics and independently of cytoplasmic bodies, ubiquitin, and proteasome activity. Perez-Caballero, D., Hatziioannou, T., Zhang, F., Cowan, S., Bieniasz, P.D. J. Virol. (2005)
- TRIM5alpha association with cytoplasmic bodies is not required for antiretroviral activity. Song, B., Diaz-Griffero, F., Park, d.o. .H., Rogers, T., Stremlau, M., Sodroski, J. Virology (2005)
- Restriction of feline immunodeficiency virus by Ref1, Lv1, and primate TRIM5alpha proteins. Saenz, D.T., Teo, W., Olsen, J.C., Poeschla, E.M. J. Virol. (2005)
- Cyclophilin A: an auxiliary but not necessary cofactor for TRIM5alpha restriction of HIV-1. Stremlau, M., Song, B., Javanbakht, H., Perron, M., Sodroski, J. Virology (2006)
- A retrovirus restriction factor TRIM5alpha is transcriptionally regulated by interferons. Asaoka, K., Ikeda, K., Hishinuma, T., Horie-Inoue, K., Takeda, S., Inoue, S. Biochem. Biophys. Res. Commun. (2005)
- Functional replacement of the RING, B-box 2, and coiled-coil domains of tripartite motif 5alpha (TRIM5alpha) by heterologous TRIM domains. Li, X., Li, Y., Stremlau, M., Yuan, W., Song, B., Perron, M., Sodroski, J. J. Virol. (2006)
- Inhibition of HIV-1 replication by simian restriction factors, TRIM5alpha and APOBEC3G. Sakuma, R., Noser, J.A., Ohmine, S., Ikeda, Y. Gene Ther. (2007)