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Gene Review

groL  -  chaperonin GroEL

Borrelia burgdorferi B31

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Disease relevance of groEL

  • Evaluation of groEL gene analysis for identification of Borrelia burgdorferi sensu lato [1].

High impact information on groEL

  • Circular DNA in the gyrB mutants was more relaxed than in wild-type cells, although groEL is on the linear chromosome of B. burgdorferi [2].
  • GroEL protein and groEL mRNA transcript were up-regulated in gyrB mutants of Borrelia burgdorferi, a causative agent of Lyme disease [2].
  • The nucleotide sequences (310 bp) of the groEL gene, which encode the 60-kDa heat shock protein GroEL from 31 reference strains of Borrelia were determined and compared [3].


  1. Evaluation of groEL gene analysis for identification of Borrelia burgdorferi sensu lato. Park, H.S., Lee, J.H., Jeong, E.J., Koh, S.E., Park, T.K., Jang, W.J., Park, K.H., Kim, B.J., Kook, Y.H., Lee, S.H. J. Clin. Microbiol. (2004) [Pubmed]
  2. groEL expression in gyrB mutants of Borrelia burgdorferi. Alverson, J., Samuels, D.S. J. Bacteriol. (2002) [Pubmed]
  3. Differentiation of Borrelia burgdorferi sensu lato through groEL gene analysis. Lee, S.H., Lee, J.H., Park, H.S., Jang, W.J., Koh, S.E., Yang, Y.M., Kim, B.J., Kook, Y.H., Park, K.H. FEMS Microbiol. Lett. (2003) [Pubmed]
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