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Gene Review:

BMEII0430 - erythritol kinase

Brucella melitensis bv. 1 str. 16M

Sperry, J.F. et al., Lillo, A.M. et al.

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Disease relevance of BMEII0430

Functional expression and characterization of EryA, the erythritol kinase of Brucella abortus, and enzymatic synthesis of L-erythritol-4-phosphate [1].

High impact information on BMEII0430

Erythritol kinase (EC 2.7.1.27; adenosine 5'-triphosphate (ATP): erythritol 1-phosphotransferase) was found to be eightfold higher in activity than the hexokinase in cell extracts [2].

Associations of BMEII0430 with chemical compounds

These data suggest bacteriostasis in the presence of erythritol results from the ATP drain caused by erythritol kinase [2].

References

Functional expression and characterization of EryA, the erythritol kinase of Brucella abortus, and enzymatic synthesis of L-erythritol-4-phosphate. Lillo, A.M., Tetzlaff, C.N., Sangari, F.J., Cane, D.E. Bioorg. Med. Chem. Lett. (2003) [Pubmed]
Inhibition of growth by erythritol catabolism in Brucella abortus. Sperry, J.F., Robertson, D.C. J. Bacteriol. (1975) [Pubmed]

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