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Gene Review

bldG  -  anti-sigma factor antagonist

Streptomyces avermitilis MA-4680

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Disease relevance of bldG


High impact information on bldG

  • Sequencing of the region downstream of bldG in S. clavuligerus revealed the presence of an open reading frame encoding a protein showing 72 and 69% identity to the ORF3 proteins in S. coelicolor and S. avermitilis, respectively [1].

Associations of bldG with chemical compounds

  • A bldG null mutant was defective in both morphological differentiation and in the production of secondary metabolites, such as cephamycin C, clavulanic acid, and the 5S clavams [1].


  1. Expression of ccaR, encoding the positive activator of cephamycin C and clavulanic acid production in Streptomyces clavuligerus, is dependent on bldG. Bignell, D.R., Tahlan, K., Colvin, K.R., Jensen, S.E., Leskiw, B.K. Antimicrob. Agents Chemother. (2005) [Pubmed]
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