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Chemical Compound Review

AC1MJ47I     (6R,7R)-7-[(5-amino-5- carboxy...

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Disease relevance of Cephamycin


High impact information on Cephamycin


Chemical compound and disease context of Cephamycin


Biological context of Cephamycin


Anatomical context of Cephamycin


Associations of Cephamycin with other chemical compounds


Gene context of Cephamycin


Analytical, diagnostic and therapeutic context of Cephamycin


  1. Genes for a beta-lactamase, a penicillin-binding protein and a transmembrane protein are clustered with the cephamycin biosynthetic genes in Nocardia lactamdurans. Coque, J.J., Liras, P., Martín, J.F. EMBO J. (1993) [Pubmed]
  2. Analysis of temporal and spatial expression of the CcaR regulatory element in the cephamycin C biosynthetic pathway using green fluorescent protein. Kyung, Y.S., Hu, W.S., Sherman, D.H. Mol. Microbiol. (2001) [Pubmed]
  3. Escherichia coli chromosomal mutations that permit direct cloning of the Bacteroides fragilis metallo-beta-lactamase gene, ccrA. Rasmussen, B.A., Gluzman, Y., Tally, F.P. Mol. Microbiol. (1991) [Pubmed]
  4. Force field design and molecular dynamics simulations of the carbapenem- and cephamycin-resistant dinuclear zinc metallo-beta-lactamase from Bacteroides fragilis and its complex with a biphenyl tetrazole inhibitor. Park, H., Merz, K.M. J. Med. Chem. (2005) [Pubmed]
  5. Delta-1-piperideine-6-carboxylate dehydrogenase, a new enzyme that forms alpha-aminoadipate in Streptomyces clavuligerus and other cephamycin C-producing actinomycetes. de La Fuente, J.L., Rumbero, A., Martín, J.F., Liras, P. Biochem. J. (1997) [Pubmed]
  6. Different proteins bind to the butyrolactone receptor protein ARE sequence located upstream of the regulatory ccaR gene of Streptomyces clavuligerus. Santamarta, I., Pérez-Redondo, R., Lorenzana, L.M., Martín, J.F., Liras, P. Mol. Microbiol. (2005) [Pubmed]
  7. Cephamycin resistance in clinical isolates and laboratory-derived strains of Escherichia coli, Nova Scotia, Canada. Clarke, B., Hiltz, M., Musgrave, H., Forward, K.R. Emerging Infect. Dis. (2003) [Pubmed]
  8. Expression of ccaR, encoding the positive activator of cephamycin C and clavulanic acid production in Streptomyces clavuligerus, is dependent on bldG. Bignell, D.R., Tahlan, K., Colvin, K.R., Jensen, S.E., Leskiw, B.K. Antimicrob. Agents Chemother. (2005) [Pubmed]
  9. Cefoxitin: a review of its antibacterial activity, pharmacological properties and therapeutic use. Brogden, R.N., Heel, R.C., Speight, T.M., Avery, G.S. Drugs (1979) [Pubmed]
  10. L-lysine epsilon-aminotransferase involved in cephamycin C synthesis in Streptomyces lactamdurans. Kern, B.A., Hendlin, D., Inamine, E. Antimicrob. Agents Chemother. (1980) [Pubmed]
  11. New cephamycin antibiotic, CS-1170: binding affinity to penicillin-binding proteins and inhibition of peptidoglycan cross-linking reactions in Escherichia coli. Ohya, S., Yamazaki, M., Sugawara, S., Tamaki, S., Matsuhashi, M. Antimicrob. Agents Chemother. (1978) [Pubmed]
  12. Cloning and characterization of the isopenicillin N synthase gene of Streptomyces griseus NRRL 3851 and studies of expression and complementation of the cephamycin pathway in Streptomyces clavuligerus. García-Domínguez, M., Liras, P., Martín, J.F. Antimicrob. Agents Chemother. (1991) [Pubmed]
  13. Increased susceptibility to cephamycin-type antibiotics of methicillin-resistant Staphylococcus aureus defective in penicillin-binding protein 2. Murakami, K., Nomura, K., Doi, M., Yoshida, T. Antimicrob. Agents Chemother. (1987) [Pubmed]
  14. Pharmacokinetics of new broad-spectrum cephamycin, YM09330, parenterally administered to various experimental animals. Komiya, M., Kikuchi, Y., Tachibana, A., Yano, K. Antimicrob. Agents Chemother. (1981) [Pubmed]
  15. Pharmacokinetics of intravenous cefmetazole with emphasis on comparison between predicted theoretical levels in tissue and actual skin window fluid levels. Tan, J.S., Salstrom, S.J., Signs, S.A., Hoffman, H.E., File, T.M. Antimicrob. Agents Chemother. (1989) [Pubmed]
  16. Amy as a reporter gene for promoter activity in Nocardia lactamdurans: comparison of promoters of the cephamycin cluster. Chary, V.K., de la Fuente, J.L., Liras, P., Martin, J.F. Appl. Environ. Microbiol. (1997) [Pubmed]
  17. The nine genes of the Nocardia lactamdurans cephamycin cluster are transcribed into large mRNAs from three promoters, two of them located in a bidirectional promoter region. Enguita, F.J., Coque, J.J., Liras, P., Martin, J.F. J. Bacteriol. (1998) [Pubmed]
  18. Investigation of the Streptomyces clavuligerus cephamycin C gene cluster and its regulation by the CcaR protein. Alexander, D.C., Jensen, S.E. J. Bacteriol. (1998) [Pubmed]
  19. Biosynthesis of a 7-alpha-methoxycephalosporin. Incorporation of molecular oxygen. O'Sullivan, J., Aplin, R.T., Stevens, C.M., Abraham, E.P. Biochem. J. (1979) [Pubmed]
  20. Effects of MT-141, a new cephamycin antibiotic, on acute urinary tract infections. Miyamoto, S., Tamiya, T., Takatsuka, K., Kumamoto, Y. Drugs under experimental and clinical research. (1985) [Pubmed]
  21. Cefotetan, a new cephamycin: comparison of in vitro antimicrobial activity with other cephems, beta-lactamase stability, and preliminary recommendations for disk diffusion testing. Ayers, L.W., Jones, R.N., Barry, A.L., Thornsberry, C., Fuchs, P.C., Gavan, T.L., Gerlach, E.H., Sommers, H.M. Antimicrob. Agents Chemother. (1982) [Pubmed]
  22. Inducing effect of diamines on transcription of the cephamycin C genes from the lat and pcbAB promoters in Nocardia lactamdurans. Leitão, A.L., Enguita, F.J., De La Fuente, J.L., Liras, P., Martin, J.F. J. Bacteriol. (1999) [Pubmed]
  23. Evaluation of three techniques for detection of low-level methicillin-resistant Staphylococcus aureus (MRSA): a disk diffusion method with cefoxitin and moxalactam, the Vitek 2 system, and the MRSA-screen latex agglutination test. Felten, A., Grandry, B., Lagrange, P.H., Casin, I. J. Clin. Microbiol. (2002) [Pubmed]
  24. Cefoxitin: single-agent treatment of mixed aerobic-anaerobic pelvic infections. Sweet, R.L., Ledger, W.J. Obstetrics and gynecology. (1979) [Pubmed]
  25. Studies of intravenous cefoxitin (MK306). Christophidis, N., Dawborn, J.K., Vajda, F.J. Med. J. Aust. (1978) [Pubmed]
  26. AmpC beta-lactamase producing multidrug resistant strains of Klebsiella spp. & Escherichia coli isolated from children under five in Chennai. Subha, A., Devi, V.R., Ananthan, S. Indian J. Med. Res. (2003) [Pubmed]
  27. Molecular mechanisms of cefoxitin resistance in Escherichia coli from the Toronto area hospitals. Forward, K.R., Willey, B.M., Low, D.E., McGeer, A., Kapala, M.A., Kapala, M.M., Burrows, L.L. Diagn. Microbiol. Infect. Dis. (2001) [Pubmed]
  28. The positive activator of cephamycin C and clavulanic acid production in Streptomyces clavuligerus is mistranslated in a bldA mutant. Trepanier, N.K., Jensen, S.E., Alexander, D.C., Leskiw, B.K. Microbiology (Reading, Engl.) (2002) [Pubmed]
  29. Cephamycin inactivation due to enzymatic hydrolysis by beta-lactamase from Bacteroides fragilis. Yotsuji, A., Minami, S., Kakizawa, H., Yasuda, T., Takai, A., Saikawa, I., Inoue, M., Mitsuhashi, S. Antimicrob. Agents Chemother. (1985) [Pubmed]
  30. In vivo selection of a cephamycin-resistant, porin-deficient mutant of Klebsiella pneumoniae producing a TEM-3 beta-lactamase. Pangon, B., Bizet, C., Buré, A., Pichon, F., Philippon, A., Regnier, B., Gutmann, L. J. Infect. Dis. (1989) [Pubmed]
  31. Time-lapsed confocal microscopy reveals temporal and spatial expression of the lysine epsilon-aminotransferase gene in Streptomyces clavuligerus. Han, L., Khetan, A., Hu, W.S., Sherman, D.H. Mol. Microbiol. (1999) [Pubmed]
  32. Pharmacokinetics of cefmetazole in normal subjects and in patients with impaired renal function. Ohkawa, M., Orito, M., Sugata, T., Shimamura, M., Sawaki, M., Nakashita, E., Kuroda, K., Sasahara, K. Antimicrob. Agents Chemother. (1980) [Pubmed]
  33. CcaR is an autoregulatory protein that binds to the ccaR and cefD-cmcI promoters of the cephamycin C-clavulanic acid cluster in Streptomyces clavuligerus. Santamarta, I., Rodríguez-García, A., Pérez-Redondo, R., Martín, J.F., Liras, P. J. Bacteriol. (2002) [Pubmed]
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