Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

hrpY - Hrp pilus subunit HRPY protein

Ralstonia solanacearum GMI1000

Huang, H.C. et al., Wei, Z. et al., Van Gijsegem, F. et al., Cunnac, S. et al.

Van Gijsegem, Vasse, Camus, Marenda, Boucher,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of hrpY

Two novel regulatory components, hrpX and hrpY, of the hrp system of Erwinia amylovora were identified [1].

High impact information on hrpY

An hrpY mutant is defective in pilus production, impaired in interactions with plants and in secretion of the PopA protein but not in attachment to plant cells [2].
The sequence of a 3.7-kb SmaI-SstI fragment covering groups VIII and IX now reveals five open reading frames (ORFs) in the same transcript, designated as hrpU, hrpW, hrpO, hrpX, and hrpY, and predicted to encode proteins of 14,795, 23,211, 9,381, 28,489, and 39,957 Da, respectively [3].

Biological context of hrpY

When hrpS or hrpL were provided on multicopy plasmids, both hrpX and hrpY mutants recovered the ability to elicit the hypersensitive reaction in tobacco [1].

Analytical, diagnostic and therapeutic context of hrpY

Site-directed mutagenesis showed that the hrp(II) box is essential for hrpY promoter activation in vivo [4].

References

Regulation of hrp genes and type III protein secretion in Erwinia amylovora by HrpX/HrpY, a novel two-component system, and HrpS. Wei, Z., Kim, J.F., Beer, S.V. Mol. Plant Microbe Interact. (2000) [Pubmed]
Ralstonia solanacearum produces hrp-dependent pili that are required for PopA secretion but not for attachment of bacteria to plant cells. Van Gijsegem, F., Vasse, J., Camus, J.C., Marenda, M., Boucher, C. Mol. Microbiol. (2000) [Pubmed]
The complete hrp gene cluster of Pseudomonas syringae pv. syringae 61 includes two blocks of genes required for harpinPss secretion that are arranged colinearly with Yersinia ysc homologs. Huang, H.C., Lin, R.H., Chang, C.J., Collmer, A., Deng, W.L. Mol. Plant Microbe Interact. (1995) [Pubmed]
Characterization of the cis-acting regulatory element controlling HrpB-mediated activation of the type III secretion system and effector genes in Ralstonia solanacearum. Cunnac, S., Boucher, C., Genin, S. J. Bacteriol. (2004) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.