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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Caml  -  calcium modulating ligand

Mus musculus

Synonyms: AI385748, CAML, Calcium signal-modulating cyclophilin ligand, Camlg
 
 
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High impact information on Caml

  • We show here that CAML is essential for peripheral T cell development [1].
  • We demonstrated that B-cell-dendritic cell (DC) interactions via transmembrane activator and calcium modulator and cyclophilin ligand (CAML) interactor (TACI) and B-lymphocyte stimulator (BLyS) provide an early signal critical to generate adequate numbers of mature antigen presenting cells (APCs) to prime naive CD8(+) T cells (CTLs) in vivo [2].
  • Murine Ptx1 was localized, by interspecific backcrossing, to Chr 13 within 2.6 cM of Caml [3].

References

  1. CAML is a p56Lck-interacting protein that is required for thymocyte development. Tran, D.D., Edgar, C.E., Heckman, K.L., Sutor, S.L., Huntoon, C.J., van Deursen, J., McKean, D.L., Bram, R.J. Immunity (2005) [Pubmed]
  2. TACI-BLyS signaling via B-cell-dendritic cell cooperation is required for naive CD8+ T-cell priming in vivo. Diaz-de-Durana, Y., Mantchev, G.T., Bram, R.J., Franco, A. Blood (2006) [Pubmed]
  3. Human and murine PTX1/Ptx1 gene maps to the region for Treacher Collins syndrome. Crawford, M.J., Lanctôt, C., Tremblay, J.J., Jenkins, N., Gilbert, D., Copeland, N., Beatty, B., Drouin, J. Mamm. Genome (1997) [Pubmed]
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