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Gene Review

CAMLG  -  calcium modulating ligand

Homo sapiens

Synonyms: CAML, Calcium signal-modulating cyclophilin ligand
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Disease relevance of CAMLG


High impact information on CAMLG

  • CAML appears to be a new participant in the calcium-signal transduction pathway, implicating cyclophilin B in calcium signalling, even in the absence of cyclosporin [2].
  • TACI-induced activation of NF-AT was specifically blocked by a dominant-negative CAML mutant, thus implicating CAML as a signaling intermediate [3].
  • The CAML (calcium-modulator and cyclophilin ligand) protein is a coinducer of NF-AT activation when overexpressed in Jurkat T cells [3].
  • The defect in these cell lines probably lies between CAML and calcineurin in the T cell activation cascade [4].
  • Fractionation of cell extracts on discontinuous sucrose gradients and indirect immunofluorescence indicate that CAML co-localizes with sarcoplasmic/endoplasmic reticulum calcium/ATPase-2 and calreticulin at membrane-bound cytosolic vesicles [5].

Biological context of CAMLG

  • The gene for calcium-modulating cyclophilin ligand (CAMLG) is located on human chromosome 5q23 and a syntenic region of mouse chromosome 13 [6].
  • The CAMLG gene encodes a novel cyclophilin B-binding protein called calcium-modulating cyclophilin ligand, which appears to be involved in the regulation of calcium signaling in T lymphocytes and other cells [6].
  • To study its function in the mouse, we disrupted the CAML gene and found it to be required for early embryonic development, but not for cellular viability [7].
  • Mutational analysis showed that K7 interaction with CAML is required for its function in the inhibition of apoptosis [8].
  • Similar to CAML, K7 expression significantly enhances the kinetics and amplitudes of the increase in intracellular Ca(2+) concentration on apoptotic stimulus [8].

Anatomical context of CAMLG

  • Calcium-modulating cyclophilin ligand (CAML) is a ubiquitous protein that has been implicated in signaling from the cell surface receptor TACI in lymphocytes, although its role and mechanism of action are unknown [7].
  • In the present study, we investigated the consequence of CAML overexpression on Ca(2+) signaling using rapid confocal imaging of Fluo3-loaded NIH3T3 fibroblasts [9].

Associations of CAMLG with chemical compounds

  • Identification of calcium-modulating cyclophilin ligand (CAML) as transducer of angiotensin II-mediated nuclear factor of activated T cells (NFAT) activation [10].
  • From the screening, we found calcium modulating cyclophilin ligand (CAML), a protein involved in Ca(2+) signaling [11].
  • Limited trypsin digests indicate that the hydrophilic NH2-terminal domain of CAML is directed toward the cytoplasm [5].
  • The human Taci gene (Transmembrane Activator and CAML Interactor) encodes a recently discovered member of the Tumor Necrosis Factor Receptor family [12].

Other interactions of CAMLG

  • FGFR1 and CAMLG were more frequently significantly overexpressed in patients with CD56 immunophenoytpe [13].


  1. Viral proteins targeting mitochondria: controlling cell death. Boya, P., Pauleau, A.L., Poncet, D., Gonzalez-Polo, R.A., Zamzami, N., Kroemer, G. Biochim. Biophys. Acta (2004) [Pubmed]
  2. Calcium signalling in T cells stimulated by a cyclophilin B-binding protein. Bram, R.J., Crabtree, G.R. Nature (1994) [Pubmed]
  3. NF-AT activation induced by a CAML-interacting member of the tumor necrosis factor receptor superfamily. von Bülow, G.U., Bram, R.J. Science (1997) [Pubmed]
  4. Isolation of mutant T lymphocytes with defects in capacitative calcium entry. Serafini, A.T., Lewis, R.S., Clipstone, N.A., Bram, R.J., Fanger, C., Fiering, S., Herzenberg, L.A., Crabtree, G.R. Immunity (1995) [Pubmed]
  5. Co-localization of calcium-modulating cyclophilin ligand with intracellular calcium pools. Holloway, M.P., Bram, R.J. J. Biol. Chem. (1998) [Pubmed]
  6. The gene for calcium-modulating cyclophilin ligand (CAMLG) is located on human chromosome 5q23 and a syntenic region of mouse chromosome 13. Bram, R.J., Valentine, V., Shapiro, D.N., Jenkins, N.A., Gilbert, D.J., Copeland, N.G. Genomics (1996) [Pubmed]
  7. CAML is required for efficient EGF receptor recycling. Tran, D.D., Russell, H.R., Sutor, S.L., van Deursen, J., Bram, R.J. Dev. Cell (2003) [Pubmed]
  8. Kaposi's sarcoma-associated herpesvirus mitochondrial K7 protein targets a cellular calcium-modulating cyclophilin ligand to modulate intracellular calcium concentration and inhibit apoptosis. Feng, P., Park, J., Lee, B.S., Lee, S.H., Bram, R.J., Jung, J.U. J. Virol. (2002) [Pubmed]
  9. Calcium-modulating cyclophilin ligand desensitizes hormone-evoked calcium release. Tovey, S.C., Bootman, M.D., Lipp, P., Berridge, M.J., Bram, R.J. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  10. Identification of calcium-modulating cyclophilin ligand (CAML) as transducer of angiotensin II-mediated nuclear factor of activated T cells (NFAT) activation. Guo, S., Lopez-Ilasaca, M., Dzau, V.J. J. Biol. Chem. (2005) [Pubmed]
  11. Fibrocystin interacts with CAML, a protein involved in Ca2+ signaling. Nagano, J., Kitamura, K., Hujer, K.M., Ward, C.J., Bram, R.J., Hopfer, U., Tomita, K., Huang, C., Miller, R.T. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  12. Molecular cloning and functional characterization of murine transmembrane activator and CAML interactor (TACI) with chromosomal localization in human and mouse. von Bülow, G.U., Russell, H., Copeland, N.G., Gilbert, D.J., Jenkins, N.A., Bram, R.J. Mamm. Genome (2000) [Pubmed]
  13. Overexpression of translocation-associated fusion genes of FGFRI, MYC, NPMI, and DEK, but absence of the translocations in acute myeloid leukemia. A microarray analysis. Larramendy, M.L., Niini, T., Elonen, E., Nagy, B., Ollila, J., Vihinen, M., Knuutila, S. Haematologica (2002) [Pubmed]
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