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MeSH Review

Antigen-Presenting Cells

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Disease relevance of Antigen-Presenting Cells


High impact information on Antigen-Presenting Cells

  • The recognition of peptide MHC class II complexes on activated antigen-presenting cells is critical for effective Th cell selection, clonal expansion, and effector Th cell function development (Phase I) [6].
  • Integrin-dependent interactions of lymphocytes and antigen-presenting cells (APCs) to endothelium regulate the efficiency and specificity of trafficking into secondary lymphoid organs and peripheral tissue [7].
  • Productive engagement of T cells by antigen-presenting cells (APCs) results in recruitment of PKC theta to the T cell-APC contact area--the immunological synapse--where it interacts with several signaling molecules to induce activation signals essential for productive T cell activation and IL-2 production [8].
  • At short times, Ca(2+) signals help to stabilize contacts between T cells and antigen-presenting cells through changes in motility and cytoskeletal reorganization [9].
  • Presentation of antigens by CD1 proteins requires uptake and intracellular processing by antigen presenting cells, and evidence exists for cellular pathways leading to the presentation of both exogenous and endogenous lipid antigens [10].

Chemical compound and disease context of Antigen-Presenting Cells


Biological context of Antigen-Presenting Cells


Anatomical context of Antigen-Presenting Cells


Associations of Antigen-Presenting Cells with chemical compounds


Gene context of Antigen-Presenting Cells


Analytical, diagnostic and therapeutic context of Antigen-Presenting Cells


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  2. Cytotoxic T cells specific for glutamic acid decarboxylase in autoimmune diabetes. Panina-Bordignon, P., Lang, R., van Endert, P.M., Benazzi, E., Felix, A.M., Pastore, R.M., Spinas, G.A., Sinigaglia, F. J. Exp. Med. (1995) [Pubmed]
  3. Modulation of susceptibility to HIV-1 infection by the cytotoxic T lymphocyte antigen 4 costimulatory molecule. Riley, J.L., Schlienger, K., Blair, P.J., Carreno, B., Craighead, N., Kim, D., Carroll, R.G., June, C.H. J. Exp. Med. (2000) [Pubmed]
  4. Transfer of hematopoietic stem cells encoding autoantigen prevents autoimmune diabetes. Steptoe, R.J., Ritchie, J.M., Harrison, L.C. J. Clin. Invest. (2003) [Pubmed]
  5. Direct binding of a myasthenia gravis related epitope to MHC class II molecules on living murine antigen-presenting cells. Mozes, E., Dayan, M., Zisman, E., Brocke, S., Licht, A., Pecht, I. EMBO J. (1989) [Pubmed]
  6. Antigen-specific memory B cell development. McHeyzer-Williams, L.J., McHeyzer-Williams, M.G. Annu. Rev. Immunol. (2005) [Pubmed]
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  8. Protein kinase C(theta) in T cell activation. Isakov, N., Altman, A. Annu. Rev. Immunol. (2002) [Pubmed]
  9. Calcium signaling mechanisms in T lymphocytes. Lewis, R.S. Annu. Rev. Immunol. (2001) [Pubmed]
  10. The CD1 system: antigen-presenting molecules for T cell recognition of lipids and glycolipids. Porcelli, S.A., Modlin, R.L. Annu. Rev. Immunol. (1999) [Pubmed]
  11. Attenuation of Th1 effector cell responses and susceptibility to experimental allergic encephalomyelitis in histamine H2 receptor knockout mice is due to dysregulation of cytokine production by antigen-presenting cells. Teuscher, C., Poynter, M.E., Offner, H., Zamora, A., Watanabe, T., Fillmore, P.D., Zachary, J.F., Blankenhorn, E.P. Am. J. Pathol. (2004) [Pubmed]
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  14. Clinical tolerance and immunologic effects after single or repeated administrations of the synthetic immunomodulator murabutide in HIV-1-infected patients. Amiel, C., De La Tribonnière, X., Vidal, V., Darcissac, E., Mouton, Y., Bahr, G.M. J. Acquir. Immune Defic. Syndr. (2002) [Pubmed]
  15. Complement receptors regulate lipopolysaccharide-induced T-cell stimulation. Kaya, Z., Tretter, T., Schlichting, J., Leuschner, F., Afanasyeva, M., Katus, H.A., Rose, N.R. Immunology (2005) [Pubmed]
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  19. T-cell specificity for H-2 and Ir gene phenotype correlates with the phenotype of thymic antigen-presenting cells. Longo, D.L., Schwartz, R.H. Nature (1980) [Pubmed]
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  23. Structure of a heterophilic adhesion complex between the human CD2 and CD58 (LFA-3) counterreceptors. Wang, J.H., Smolyar, A., Tan, K., Liu, J.H., Kim, M., Sun, Z.Y., Wagner, G., Reinherz, E.L. Cell (1999) [Pubmed]
  24. Endogenous superantigen expression controlled by a novel promoter in the MMTV long terminal repeat. Günzburg, W.H., Heinemann, F., Wintersperger, S., Miethke, T., Wagner, H., Erfle, V., Salmons, B. Nature (1993) [Pubmed]
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  27. T-cell engagement of dendritic cells rapidly rearranges MHC class II transport. Boes, M., Cerny, J., Massol, R., Op den Brouw, M., Kirchhausen, T., Chen, J., Ploegh, H.L. Nature (2002) [Pubmed]
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  29. N-linked glycan modification on antigen-presenting cells restores an allospecific cytotoxic T cell response. Neefjes, J.J., De Bruijn, M.L., Boog, C.J., Nieland, J.D., Boes, J., Melief, C.J., Ploegh, H.L. J. Exp. Med. (1990) [Pubmed]
  30. Thiol-mediated redox regulation of intestinal lamina propria T lymphocytes. Sido, B., Braunstein, J., Breitkreutz, R., Herfarth, C., Meuer, S.C. J. Exp. Med. (2000) [Pubmed]
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  32. HLA-DMA and -DMB genes are both required for MHC class II/peptide complex formation in antigen-presenting cells. Fling, S.P., Arp, B., Pious, D. Nature (1994) [Pubmed]
  33. B7h, a novel costimulatory homolog of B7.1 and B7.2, is induced by TNFalpha. Swallow, M.M., Wallin, J.J., Sha, W.C. Immunity (1999) [Pubmed]
  34. Residual MHC class II expression on mature dendritic cells and activated B cells in RFX5-deficient mice. Clausen, B.E., Waldburger, J.M., Schwenk, F., Barras, E., Mach, B., Rajewsky, K., Förster, I., Reith, W. Immunity (1998) [Pubmed]
  35. Vav1 controls integrin clustering and MHC/peptide-specific cell adhesion to antigen-presenting cells. Krawczyk, C., Oliveira-dos-Santos, A., Sasaki, T., Griffiths, E., Ohashi, P.S., Snapper, S., Alt, F., Penninger, J.M. Immunity (2002) [Pubmed]
  36. Tolerance is dependent on complement C3 fragment iC3b binding to antigen-presenting cells. Sohn, J.H., Bora, P.S., Suk, H.J., Molina, H., Kaplan, H.J., Bora, N.S. Nat. Med. (2003) [Pubmed]
  37. Non-hematopoietic allograft cells directly activate CD8+ T cells and trigger acute rejection: an alternative mechanism of allorecognition. Kreisel, D., Krupnick, A.S., Gelman, A.E., Engels, F.H., Popma, S.H., Krasinskas, A.M., Balsara, K.R., Szeto, W.Y., Turka, L.A., Rosengard, B.R. Nat. Med. (2002) [Pubmed]
  38. Dendritic cell progenitors phagocytose particulates, including bacillus Calmette-Guerin organisms, and sensitize mice to mycobacterial antigens in vivo. Inaba, K., Inaba, M., Naito, M., Steinman, R.M. J. Exp. Med. (1993) [Pubmed]
  39. Microsomal triglyceride transfer protein lipidation and control of CD1d on antigen-presenting cells. Dougan, S.K., Salas, A., Rava, P., Agyemang, A., Kaser, A., Morrison, J., Khurana, A., Kronenberg, M., Johnson, C., Exley, M., Hussain, M.M., Blumberg, R.S. J. Exp. Med. (2005) [Pubmed]
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