The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

Antigen-Presenting Cells

 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of Antigen-Presenting Cells

 

High impact information on Antigen-Presenting Cells

  • The recognition of peptide MHC class II complexes on activated antigen-presenting cells is critical for effective Th cell selection, clonal expansion, and effector Th cell function development (Phase I) [6].
  • Integrin-dependent interactions of lymphocytes and antigen-presenting cells (APCs) to endothelium regulate the efficiency and specificity of trafficking into secondary lymphoid organs and peripheral tissue [7].
  • Productive engagement of T cells by antigen-presenting cells (APCs) results in recruitment of PKC theta to the T cell-APC contact area--the immunological synapse--where it interacts with several signaling molecules to induce activation signals essential for productive T cell activation and IL-2 production [8].
  • At short times, Ca(2+) signals help to stabilize contacts between T cells and antigen-presenting cells through changes in motility and cytoskeletal reorganization [9].
  • Presentation of antigens by CD1 proteins requires uptake and intracellular processing by antigen presenting cells, and evidence exists for cellular pathways leading to the presentation of both exogenous and endogenous lipid antigens [10].
 

Chemical compound and disease context of Antigen-Presenting Cells

 

Biological context of Antigen-Presenting Cells

 

Anatomical context of Antigen-Presenting Cells

 

Associations of Antigen-Presenting Cells with chemical compounds

 

Gene context of Antigen-Presenting Cells

 

Analytical, diagnostic and therapeutic context of Antigen-Presenting Cells

References

  1. Measles virus transmembrane fusion protein synthesized de novo or presented in immunostimulating complexes is endogenously processed for HLA class I- and class II-restricted cytotoxic T cell recognition. van Binnendijk, R.S., van Baalen, C.A., Poelen, M.C., de Vries, P., Boes, J., Cerundolo, V., Osterhaus, A.D., UytdeHaag, F.G. J. Exp. Med. (1992) [Pubmed]
  2. Cytotoxic T cells specific for glutamic acid decarboxylase in autoimmune diabetes. Panina-Bordignon, P., Lang, R., van Endert, P.M., Benazzi, E., Felix, A.M., Pastore, R.M., Spinas, G.A., Sinigaglia, F. J. Exp. Med. (1995) [Pubmed]
  3. Modulation of susceptibility to HIV-1 infection by the cytotoxic T lymphocyte antigen 4 costimulatory molecule. Riley, J.L., Schlienger, K., Blair, P.J., Carreno, B., Craighead, N., Kim, D., Carroll, R.G., June, C.H. J. Exp. Med. (2000) [Pubmed]
  4. Transfer of hematopoietic stem cells encoding autoantigen prevents autoimmune diabetes. Steptoe, R.J., Ritchie, J.M., Harrison, L.C. J. Clin. Invest. (2003) [Pubmed]
  5. Direct binding of a myasthenia gravis related epitope to MHC class II molecules on living murine antigen-presenting cells. Mozes, E., Dayan, M., Zisman, E., Brocke, S., Licht, A., Pecht, I. EMBO J. (1989) [Pubmed]
  6. Antigen-specific memory B cell development. McHeyzer-Williams, L.J., McHeyzer-Williams, M.G. Annu. Rev. Immunol. (2005) [Pubmed]
  7. Integrins and T cell-mediated immunity. Pribila, J.T., Quale, A.C., Mueller, K.L., Shimizu, Y. Annu. Rev. Immunol. (2004) [Pubmed]
  8. Protein kinase C(theta) in T cell activation. Isakov, N., Altman, A. Annu. Rev. Immunol. (2002) [Pubmed]
  9. Calcium signaling mechanisms in T lymphocytes. Lewis, R.S. Annu. Rev. Immunol. (2001) [Pubmed]
  10. The CD1 system: antigen-presenting molecules for T cell recognition of lipids and glycolipids. Porcelli, S.A., Modlin, R.L. Annu. Rev. Immunol. (1999) [Pubmed]
  11. Attenuation of Th1 effector cell responses and susceptibility to experimental allergic encephalomyelitis in histamine H2 receptor knockout mice is due to dysregulation of cytokine production by antigen-presenting cells. Teuscher, C., Poynter, M.E., Offner, H., Zamora, A., Watanabe, T., Fillmore, P.D., Zachary, J.F., Blankenhorn, E.P. Am. J. Pathol. (2004) [Pubmed]
  12. Deficient cytokine response of human allergen-specific T lymphocytes from humanized SCID mice and reconstitution by professional antigen-presenting cells. Jarman, E.R., Perschke, K., Montermann, E., Herz, U., Renz, H., Knop, J., Reske-Kunz, A.B. J. Allergy Clin. Immunol. (2000) [Pubmed]
  13. Effects of chloroquine on antigen-presenting functions of epidermal cells from normal and psoriatic skin. Demidem, A., Taylor, J.R., Grammer, S.F., Streilein, J.W. J. Invest. Dermatol. (1992) [Pubmed]
  14. Clinical tolerance and immunologic effects after single or repeated administrations of the synthetic immunomodulator murabutide in HIV-1-infected patients. Amiel, C., De La Tribonnière, X., Vidal, V., Darcissac, E., Mouton, Y., Bahr, G.M. J. Acquir. Immune Defic. Syndr. (2002) [Pubmed]
  15. Complement receptors regulate lipopolysaccharide-induced T-cell stimulation. Kaya, Z., Tretter, T., Schlichting, J., Leuschner, F., Afanasyeva, M., Katus, H.A., Rose, N.R. Immunology (2005) [Pubmed]
  16. Capture and processing of exogenous antigens for presentation on MHC molecules. Watts, C. Annu. Rev. Immunol. (1997) [Pubmed]
  17. A kinetic intermediate in the reaction of an antigenic peptide and I-Ek. Sadegh-Nasseri, S., McConnell, H.M. Nature (1989) [Pubmed]
  18. Inserted H-2 gene membrane products mediate immune response phenotype of antigen-presenting cell. Jakobovits, A., Frenkel, A., Sharon, N., Cohen, I.R. Nature (1981) [Pubmed]
  19. T-cell specificity for H-2 and Ir gene phenotype correlates with the phenotype of thymic antigen-presenting cells. Longo, D.L., Schwartz, R.H. Nature (1980) [Pubmed]
  20. Hsp70 promotes antigen-presenting cell function and converts T-cell tolerance to autoimmunity in vivo. Millar, D.G., Garza, K.M., Odermatt, B., Elford, A.R., Ono, N., Li, Z., Ohashi, P.S. Nat. Med. (2003) [Pubmed]
  21. The dendritic cell system and its role in immunogenicity. Steinman, R.M. Annu. Rev. Immunol. (1991) [Pubmed]
  22. Differential regulation of murine T lymphocyte subsets. Fitch, F.W., McKisic, M.D., Lancki, D.W., Gajewski, T.F. Annu. Rev. Immunol. (1993) [Pubmed]
  23. Structure of a heterophilic adhesion complex between the human CD2 and CD58 (LFA-3) counterreceptors. Wang, J.H., Smolyar, A., Tan, K., Liu, J.H., Kim, M., Sun, Z.Y., Wagner, G., Reinherz, E.L. Cell (1999) [Pubmed]
  24. Endogenous superantigen expression controlled by a novel promoter in the MMTV long terminal repeat. Günzburg, W.H., Heinemann, F., Wintersperger, S., Miethke, T., Wagner, H., Erfle, V., Salmons, B. Nature (1993) [Pubmed]
  25. Epidermal Langerhans cells are derived from cells originating in bone marrow. Katz, S.I., Tamaki, K., Sachs, D.H. Nature (1979) [Pubmed]
  26. The chondroitin sulfate form of invariant chain can enhance stimulation of T cell responses through interaction with CD44. Naujokas, M.F., Morin, M., Anderson, M.S., Peterson, M., Miller, J. Cell (1993) [Pubmed]
  27. T-cell engagement of dendritic cells rapidly rearranges MHC class II transport. Boes, M., Cerny, J., Massol, R., Op den Brouw, M., Kirchhausen, T., Chen, J., Ploegh, H.L. Nature (2002) [Pubmed]
  28. Staging and resetting T cell activation in SMACs. Freiberg, B.A., Kupfer, H., Maslanik, W., Delli, J., Kappler, J., Zaller, D.M., Kupfer, A. Nat. Immunol. (2002) [Pubmed]
  29. N-linked glycan modification on antigen-presenting cells restores an allospecific cytotoxic T cell response. Neefjes, J.J., De Bruijn, M.L., Boog, C.J., Nieland, J.D., Boes, J., Melief, C.J., Ploegh, H.L. J. Exp. Med. (1990) [Pubmed]
  30. Thiol-mediated redox regulation of intestinal lamina propria T lymphocytes. Sido, B., Braunstein, J., Breitkreutz, R., Herfarth, C., Meuer, S.C. J. Exp. Med. (2000) [Pubmed]
  31. The role of the CD28 receptor during T cell responses to antigen. Linsley, P.S., Ledbetter, J.A. Annu. Rev. Immunol. (1993) [Pubmed]
  32. HLA-DMA and -DMB genes are both required for MHC class II/peptide complex formation in antigen-presenting cells. Fling, S.P., Arp, B., Pious, D. Nature (1994) [Pubmed]
  33. B7h, a novel costimulatory homolog of B7.1 and B7.2, is induced by TNFalpha. Swallow, M.M., Wallin, J.J., Sha, W.C. Immunity (1999) [Pubmed]
  34. Residual MHC class II expression on mature dendritic cells and activated B cells in RFX5-deficient mice. Clausen, B.E., Waldburger, J.M., Schwenk, F., Barras, E., Mach, B., Rajewsky, K., Förster, I., Reith, W. Immunity (1998) [Pubmed]
  35. Vav1 controls integrin clustering and MHC/peptide-specific cell adhesion to antigen-presenting cells. Krawczyk, C., Oliveira-dos-Santos, A., Sasaki, T., Griffiths, E., Ohashi, P.S., Snapper, S., Alt, F., Penninger, J.M. Immunity (2002) [Pubmed]
  36. Tolerance is dependent on complement C3 fragment iC3b binding to antigen-presenting cells. Sohn, J.H., Bora, P.S., Suk, H.J., Molina, H., Kaplan, H.J., Bora, N.S. Nat. Med. (2003) [Pubmed]
  37. Non-hematopoietic allograft cells directly activate CD8+ T cells and trigger acute rejection: an alternative mechanism of allorecognition. Kreisel, D., Krupnick, A.S., Gelman, A.E., Engels, F.H., Popma, S.H., Krasinskas, A.M., Balsara, K.R., Szeto, W.Y., Turka, L.A., Rosengard, B.R. Nat. Med. (2002) [Pubmed]
  38. Dendritic cell progenitors phagocytose particulates, including bacillus Calmette-Guerin organisms, and sensitize mice to mycobacterial antigens in vivo. Inaba, K., Inaba, M., Naito, M., Steinman, R.M. J. Exp. Med. (1993) [Pubmed]
  39. Microsomal triglyceride transfer protein lipidation and control of CD1d on antigen-presenting cells. Dougan, S.K., Salas, A., Rava, P., Agyemang, A., Kaser, A., Morrison, J., Khurana, A., Kronenberg, M., Johnson, C., Exley, M., Hussain, M.M., Blumberg, R.S. J. Exp. Med. (2005) [Pubmed]
  40. The fate of human Langerhans cells in hematopoietic stem cell transplantation. Collin, M.P., Hart, D.N., Jackson, G.H., Cook, G., Cavet, J., Mackinnon, S., Middleton, P.G., Dickinson, A.M. J. Exp. Med. (2006) [Pubmed]
 
WikiGenes - Universities