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Gene Review: 

Car7  -  carbonic anhydrase 7

Mus musculus

Synonyms: AV343731, CA-VII, Ca7, Carbonate dehydratase VII, Carbonic anhydrase 7, ...
 
 
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Disease relevance of Car7

 

High impact information on Car7

  • Unlike the other isozymes of this class of CA, for which Kcat/K(m) is described by the single ionization of zinc-bound water, CA VII exhibits a pH profile for Kcat/K(m) for CO2 hydration described by two ionizations at pKa 6.2 and 7.5, with a maximum approaching 8 x 10(7) M-1 s-1 [2].
  • In the cerebellum, both Car7 and Car8 were transcribed to different degrees in the Purkinje cells, and a lower expression level occurred in the molecular and granular cell layers [3].
 

Associations of Car7 with chemical compounds

  • Although the gene for human CA VII has been cloned and characterized, the corresponding protein has not previously been purified, and hence, the CO2 hydrase activity of its product has not as yet been demonstrated [1].

References

  1. Expression of mouse carbonic anhydrase VII in E. coli and demonstration of its CO2 hydrase activity. Lakkis, M.M., Bergenhem, N.C., Tashian, R.E. Biochem. Biophys. Res. Commun. (1996) [Pubmed]
  2. The catalytic properties of murine carbonic anhydrase VII. Earnhardt, J.N., Qian, M., Tu, C., Lakkis, M.M., Bergenhem, N.C., Laipis, P.J., Tashian, R.E., Silverman, D.N. Biochemistry (1998) [Pubmed]
  3. Differential expression of the carbonic anhydrase genes for CA VII (Car7) and CA-RP VIII (Car8) in mouse brain. Lakkis, M.M., O'Shea, K.S., Tashian, R.E. J. Histochem. Cytochem. (1997) [Pubmed]
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