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MeSH Review

Purkinje Cells

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Chemical compound and disease context of Purkinje Cells


Biological context of Purkinje Cells


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Gene context of Purkinje Cells


Analytical, diagnostic and therapeutic context of Purkinje Cells


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  2. Mutation of a new sodium channel gene, Scn8a, in the mouse mutant 'motor endplate disease'. Burgess, D.L., Kohrman, D.C., Galt, J., Plummer, N.W., Jones, J.M., Spear, B., Meisler, M.H. Nat. Genet. (1995) [Pubmed]
  3. RNAi suppresses polyglutamine-induced neurodegeneration in a model of spinocerebellar ataxia. Xia, H., Mao, Q., Eliason, S.L., Harper, S.Q., Martins, I.H., Orr, H.T., Paulson, H.L., Yang, L., Kotin, R.M., Davidson, B.L. Nat. Med. (2004) [Pubmed]
  4. Neurotrophin-3 induced by tri-iodothyronine in cerebellar granule cells promotes Purkinje cell differentiation. Lindholm, D., Castrén, E., Tsoulfas, P., Kolbeck, R., Berzaghi, M.d.a. .P., Leingärtner, A., Heisenberg, C.P., Tessarollo, L., Parada, L.F., Thoenen, H., Tesarollo, L. J. Cell Biol. (1993) [Pubmed]
  5. Sensory neuron-specific sodium channel SNS is abnormally expressed in the brains of mice with experimental allergic encephalomyelitis and humans with multiple sclerosis. Black, J.A., Dib-Hajj, S., Baker, D., Newcombe, J., Cuzner, M.L., Waxman, S.G. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  6. Decreased expression of AMPA receptor messenger RNA and protein in AIDS: a model for HIV-associated neurotoxicity. Everall, I.P., Hudson, L., al-Sarraj, S., Honavar, M., Lantos, P., Kerwin, R. Nat. Med. (1995) [Pubmed]
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  8. Expression of nestin in Purkinje cells in patients with Creutzfeldt-Jakob disease. Mizuno, Y., Takeuchi, T., Takatama, M., Okamoto, K. Neurosci. Lett. (2003) [Pubmed]
  9. The critical period of Purkinje cell degeneration and cerebellar hypoplasia due to bilirubin. Takagishi, Y., Yamamura, H. Acta Neuropathol. (1987) [Pubmed]
  10. Serotonin drives a novel GABAergic synaptic current recorded in rat cerebellar purkinje cells: a Lugaro cell to Purkinje cell synapse. Dean, I., Robertson, S.J., Edwards, F.A. J. Neurosci. (2003) [Pubmed]
  11. Spectrin mutations cause spinocerebellar ataxia type 5. Ikeda, Y., Dick, K.A., Weatherspoon, M.R., Gincel, D., Armbrust, K.R., Dalton, J.C., Stevanin, G., Dürr, A., Zühlke, C., Bürk, K., Clark, H.B., Brice, A., Rothstein, J.D., Schut, L.J., Day, J.W., Ranum, L.P. Nat. Genet. (2006) [Pubmed]
  12. Monoallelic yet combinatorial expression of variable exons of the protocadherin-alpha gene cluster in single neurons. Esumi, S., Kakazu, N., Taguchi, Y., Hirayama, T., Sasaki, A., Hirabayashi, T., Koide, T., Kitsukawa, T., Hamada, S., Yagi, T. Nat. Genet. (2005) [Pubmed]
  13. The AXH domain of Ataxin-1 mediates neurodegeneration through its interaction with Gfi-1/Senseless proteins. Tsuda, H., Jafar-Nejad, H., Patel, A.J., Sun, Y., Chen, H.K., Rose, M.F., Venken, K.J., Botas, J., Orr, H.T., Bellen, H.J., Zoghbi, H.Y. Cell (2005) [Pubmed]
  14. Nuclear localization or inclusion body formation of ataxin-2 are not necessary for SCA2 pathogenesis in mouse or human. Huynh, D.P., Figueroa, K., Hoang, N., Pulst, S.M. Nat. Genet. (2000) [Pubmed]
  15. Impairment of motor coordination, Purkinje cell synapse formation, and cerebellar long-term depression in GluR delta 2 mutant mice. Kashiwabuchi, N., Ikeda, K., Araki, K., Hirano, T., Shibuki, K., Takayama, C., Inoue, Y., Kutsuwada, T., Yagi, T., Kang, Y. Cell (1995) [Pubmed]
  16. AMPA receptor desensitization predicts the selective vulnerability of cerebellar Purkinje cells to excitotoxicity. Brorson, J.R., Manzolillo, P.A., Gibbons, S.J., Miller, R.J. J. Neurosci. (1995) [Pubmed]
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  18. Linalool suppresses voltage-gated currents in sensory neurons and cerebellar Purkinje cells. Narusuye, K., Kawai, F., Matsuzaki, K., Miyachi, E. Journal of neural transmission (Vienna, Austria : 1996) (2005) [Pubmed]
  19. Inositol 1,4,5-triphosphate receptor protein immunohistochemistry of cerebellar Purkinje cells in two dogs with hypoglycemia. Morita, T., Nakamura, K., Sawada, M., Shimada, A., Sato, K., Miyata, H., Ohama, E. Vet. Pathol. (2004) [Pubmed]
  20. Osmotic sensitivity of taurine release from hippocampal neuronal and glial cells. Olson, J.E., Li, G.Z. Adv. Exp. Med. Biol. (2000) [Pubmed]
  21. Dynamic organization of developing Purkinje cells revealed by transgene expression. Smeyne, R.J., Oberdick, J., Schilling, K., Berrebi, A.S., Mugnaini, E., Morgan, J.I. Science (1991) [Pubmed]
  22. Postsynaptic glutamate transport at the climbing fiber-Purkinje cell synapse. Otis, T.S., Kavanaugh, M.P., Jahr, C.E. Science (1997) [Pubmed]
  23. Transient and persistent phosphorylation of AMPA-type glutamate receptor subunits in cerebellar Purkinje cells. Nakazawa, K., Mikawa, S., Hashikawa, T., Ito, M. Neuron (1995) [Pubmed]
  24. Deficient cerebellar long-term depression, impaired eyeblink conditioning, and normal motor coordination in GFAP mutant mice. Shibuki, K., Gomi, H., Chen, L., Bao, S., Kim, J.J., Wakatsuki, H., Fujisaki, T., Fujimoto, K., Katoh, A., Ikeda, T., Chen, C., Thompson, R.F., Itohara, S. Neuron (1996) [Pubmed]
  25. Imprinting in Angelman and Prader-Willi syndromes. Jiang, Y., Tsai, T.F., Bressler, J., Beaudet, A.L. Curr. Opin. Genet. Dev. (1998) [Pubmed]
  26. Ataxia and epileptic seizures in mice lacking type 1 inositol 1,4,5-trisphosphate receptor. Matsumoto, M., Nakagawa, T., Inoue, T., Nagata, E., Tanaka, K., Takano, H., Minowa, O., Kuno, J., Sakakibara, S., Yamada, M., Yoneshima, H., Miyawaki, A., Fukuuchi, Y., Furuichi, T., Okano, H., Mikoshiba, K., Noda, T. Nature (1996) [Pubmed]
  27. Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression. Makino, Y., Cao, R., Svensson, K., Bertilsson, G., Asman, M., Tanaka, H., Cao, Y., Berkenstam, A., Poellinger, L. Nature (2001) [Pubmed]
  28. Calcium entry increases the sensitivity of cerebellar Purkinje cells to applied GABA and decreases inhibitory synaptic currents. Llano, I., Leresche, N., Marty, A. Neuron (1991) [Pubmed]
  29. Distinctive biophysical and pharmacological properties of class A (BI) calcium channel alpha 1 subunits. Sather, W.A., Tanabe, T., Zhang, J.F., Mori, Y., Adams, M.E., Tsien, R.W. Neuron (1993) [Pubmed]
  30. The neuropeptide cerebellin is a marker for two similar neuronal circuits in rat brain. Mugnaini, E., Morgan, J.I. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  31. Acid sphingomyelinase deficient mice: a model of types A and B Niemann-Pick disease. Horinouchi, K., Erlich, S., Perl, D.P., Ferlinz, K., Bisgaier, C.L., Sandhoff, K., Desnick, R.J., Stewart, C.L., Schuchman, E.H. Nat. Genet. (1995) [Pubmed]
  32. Selective activation of calcium permeability by aspartate in Purkinje cells. Yuzaki, M., Forrest, D., Curran, T., Connor, J.A. Science (1996) [Pubmed]
  33. Analogs of cyclic adenosine monophosphate: correlation of inhibition of Purkinje Neurons with Protein Kinase Activation. Siggins, G.R., Henriksen, S.J. Science (1975) [Pubmed]
  34. Autoradiographic imaging of phosphoinositide turnover in the brain. Hwang, P.M., Bredt, D.S., Snyder, S.H. Science (1990) [Pubmed]
  35. Selective extraction of small and large molecules from the cerebrospinal fluid by Purkinje neurons. Borges, L.F., Elliott, P.J., Gill, R., Iversen, S.D., Iversen, L.L. Science (1985) [Pubmed]
  36. The cerebellar leucine-rich acidic nuclear protein interacts with ataxin-1. Matilla, A., Koshy, B.T., Cummings, C.J., Isobe, T., Orr, H.T., Zoghbi, H.Y. Nature (1997) [Pubmed]
  37. Neurotrophins promote the survival and development of neurons in the cerebellum of hypothyroid rats in vivo. Neveu, I., Arenas, E. J. Cell Biol. (1996) [Pubmed]
  38. Boat, an AXH domain protein, suppresses the cytotoxicity of mutant ataxin-1. Mizutani, A., Wang, L., Rajan, H., Vig, P.J., Alaynick, W.A., Thaler, J.P., Tsai, C.C. EMBO J. (2005) [Pubmed]
  39. Purkinje cell degeneration associated with erythroid ankyrin deficiency in nb/nb mice. Peters, L.L., Birkenmeier, C.S., Bronson, R.T., White, R.A., Lux, S.E., Otto, E., Bennett, V., Higgins, A., Barker, J.E. J. Cell Biol. (1991) [Pubmed]
  40. A calcium responsive element that regulates expression of two calcium binding proteins in Purkinje cells. Arnold, D.B., Heintz, N. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  41. Neuronal influence on glial enzyme expression: evidence from chimeric mouse cerebellum. Fisher, M., Mullen, R.J. Neuron (1988) [Pubmed]
  42. Native structure and arrangement of inositol-1,4,5-trisphosphate receptor molecules in bovine cerebellar Purkinje cells as studied by quick-freeze deep-etch electron microscopy. Katayama, E., Funahashi, H., Michikawa, T., Shiraishi, T., Ikemoto, T., Iino, M., Mikoshiba, K. EMBO J. (1996) [Pubmed]
  43. Immunofluorescence localization of thyroid hormone receptor protein beta 1 and variant alpha 2 in selected tissues: cerebellar Purkinje cells as a model for beta 1 receptor-mediated developmental effects of thyroid hormone in brain. Strait, K.A., Schwartz, H.L., Seybold, V.S., Ling, N.C., Oppenheimer, J.H. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  44. Expansion of the polyQ repeat in ataxin-2 alters its Golgi localization, disrupts the Golgi complex and causes cell death. Huynh, D.P., Yang, H.T., Vakharia, H., Nguyen, D., Pulst, S.M. Hum. Mol. Genet. (2003) [Pubmed]
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