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Gene Review

CA7  -  carbonic anhydrase VII

Homo sapiens

Synonyms: CA-VII, Carbonate dehydratase VII, Carbonic anhydrase 7, Carbonic anhydrase VII
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Disease relevance of CA7


High impact information on CA7

  • The flanking markers CA7 and D2S378 defined a region of approximately 6.4 cM that is likely to contain the gene(s) associated with Carney complex [2].
  • PCR analysis of DNAs from human-rodent somatic cell hybrids localized the gene for CA V to human chromosome 16, the same chromosome to which CA VII has previously been mapped [3].
  • In addition, factors influencing the trafficking and kinetic modulation of KCC2 as well as activation/deactivation of CAVII are obvious candidates in the ionic modulation of GABAergic responses [4].
  • Like the CA VII gene, CA5 does not contain typical TATA and CAAT promoter elements in the 5' flanking region but does contain a TTTAA sequence 147 nucleotides upstream of the initiation codon [5].
  • The exon-intron boundaries are found in positions identical to those determined for the previously described CA II, CA III, and CA VII genes [5].

Biological context of CA7

  • Characterization of the human gene for a newly discovered carbonic anhydrase, CA VII, and its localization to chromosome 16 [6].
  • The 5' flanking regions of the CA VII gene do not contain the TATA and CAAT promoter elements usually found within 100 bp upstream of transcription initiation, but do contain a TTTAA sequence 102 nucleotides upstream of the initiation codon [6].
  • We have isolated an additional CA gene from a human genomic library and designated its putative product carbonic anhydrase VII (CA VII) [6].
  • When the available molecular sequence information is examined, it is evident that the erythrocyte CAs of early vertebrates have active sites that are more similar to those of mammalian CA VII and II, rather than CA I [7].

Anatomical context of CA7


Associations of CA7 with chemical compounds


Other interactions of CA7

  • The potential for the identification and quantification of individual branched carboxyalkyl isomeric mixtures of CA5-, CA6-, CA7-, and CA8P1EC metabolites based on corresponding dm-CA5-8P1ECs revealed the advantage of the GC-CI-MS although the detection limits in CI were clearly higher than those in EI [10].


  1. First experiences with high-density silicone oil (Densiron) as an intraocular tamponade in complex retinal detachment. Sandner, D., Engelmann, K. Graefes Arch. Clin. Exp. Ophthalmol. (2006) [Pubmed]
  2. Carney complex, a familial multiple neoplasia and lentiginosis syndrome. Analysis of 11 kindreds and linkage to the short arm of chromosome 2. Stratakis, C.A., Carney, J.A., Lin, J.P., Papanicolaou, D.A., Karl, M., Kastner, D.L., Pras, E., Chrousos, G.P. J. Clin. Invest. (1996) [Pubmed]
  3. Human mitochondrial carbonic anhydrase: cDNA cloning, expression, subcellular localization, and mapping to chromosome 16. Nagao, Y., Platero, J.S., Waheed, A., Sly, W.S. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  4. Two developmental switches in GABAergic signalling: the K+-Cl- cotransporter KCC2 and carbonic anhydrase CAVII. Rivera, C., Voipio, J., Kaila, K. J. Physiol. (Lond.) (2005) [Pubmed]
  5. Genomic organization of the human gene (CA5) and pseudogene for mitochondrial carbonic anhydrase V and their localization to chromosomes 16q and 16p. Nagao, Y., Batanian, J.R., Clemente, M.F., Sly, W.S. Genomics (1995) [Pubmed]
  6. Characterization of the human gene for a newly discovered carbonic anhydrase, CA VII, and its localization to chromosome 16. Montgomery, J.C., Venta, P.J., Eddy, R.L., Fukushima, Y.S., Shows, T.B., Tashian, R.E. Genomics (1991) [Pubmed]
  7. Comparative physiology and molecular evolution of carbonic anhydrase in the erythrocytes of early vertebrates. Tufts, B.L., Esbaugh, A., Lund, S.G. Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. (2003) [Pubmed]
  8. Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isozyme VII with aromatic and heterocyclic sulfonamides. Vullo, D., Voipio, J., Innocenti, A., Rivera, C., Ranki, H., Scozzafava, A., Kaila, K., Supuran, C.T. Bioorg. Med. Chem. Lett. (2005) [Pubmed]
  9. Carbonic anhydrase inhibitors: Inhibition of the cytosolic human isozyme VII with anions. Vullo, D., Ruusuvuori, E., Kaila, K., Scozzafava, A., Supuran, C.T. Bioorg. Med. Chem. Lett. (2006) [Pubmed]
  10. Dicarboxylic degradation products of nonylphenol polyethoxylates: synthesis and identification by gas chromatography-mass spectrometry using electron and chemical ionization modes. Hoai, P.M., Tsunoi, S., Ike, M., Inui, N., Tanaka, M., Fujita, M. Journal of chromatography. A. (2004) [Pubmed]
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