Gene Review:
pilQ - type IV pilus biogenesis ATPase PilQ
Escherichia coli
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Disease relevance of pilQ
- The piliation defects in the mutants could not be ascribed to polarity on distal pilQ expression as shown by direct measurement of PilQ antigen in those backgrounds and the use of a novel technique to create tandem duplications in the gonococcus (Gc) genome [1].
- DNA sequencing of the region upstream of pilQ revealed the presence of two open reading frames (ORFs) whose deduced polypeptides shared significant identities with proteins required for pilus expression in Pseudomonas aeruginosa and Pseudomonas syringae, the genes for which are arrayed upstream of a gene encoding a PilQ homologue [1].
References
- PilP, a pilus biogenesis lipoprotein in Neisseria gonorrhoeae, affects expression of PilQ as a high-molecular-mass multimer. Drake, S.L., Sandstedt, S.A., Koomey, M. Mol. Microbiol. (1997) [Pubmed]
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