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Gene Review

Cbx4  -  chromobox 4

Mus musculus

Synonyms: Chromobox protein homolog 4, E3 SUMO-protein ligase CBX4, MPc2, PC2, Pc2, ...
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High impact information on Cbx4

  • MPc3 is a recently described mouse Polycomb (Pc) protein that shares structural homology with at least two other Pc proteins, M33 and MPc2 [1].
  • Co-immunoprecipitations and subnuclear co-localization studies show that MPc2 interacts with the mouse polycomb-group oncoprotein Bmi1 and is a new member of the mouse polycomb multiprotein complex [2].
  • Here, we report the cloning and characterization of a novel mouse polycomb homolog, MPc2, in addition to the previously described M33 polycomb gene [2].
  • Gal4DB-MPc2 or -M33 fusion proteins mediate a five- to tenfold repression of stably integrated reporter constructs carrying GAL4 binding sites, demonstrating that these proteins are transcriptional repressors [2].


  1. The polycomb protein MPc3 interacts with AF9, an MLL fusion partner in t(9;11)(p22;q23) acute leukemias. Hemenway, C.S., de Erkenez, A.C., Gould, G.C. Oncogene (2001) [Pubmed]
  2. MPc2, a new murine homolog of the Drosophila polycomb protein is a member of the mouse polycomb transcriptional repressor complex. Alkema, M.J., Jacobs, J., Voncken, J.W., Jenkins, N.A., Copeland, N.G., Satijn, D.P., Otte, A.P., Berns, A., van Lohuizen, M. J. Mol. Biol. (1997) [Pubmed]
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