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Gene Review

fimZ  -  transcriptional regulator FimZ

Salmonella enterica subsp. enterica serovar Typhimurium str. LT2

 
 
 
 
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Disease relevance of fimZ

 

High impact information on fimZ

  • One of these genes, fimZ, appears to be involved in increasing the expression of fimA [1].
  • An examination of the predicted amino acid sequence, deduced from the nucleotide sequence of fimZ, indicated that the FimZ polypeptide possessed a DNA binding motif [1].
  • The fimZ mutant demonstrated decreased levels of fimA expression compared with the parental strain when both were grown under conditions favoring fimbrial expression [1].
 

Biological context of fimZ

  • Bacterial lysates, derived from strains transformed with recombinant plasmids possessing a fimZ gene, demonstrated DNA binding activity with a fragment containing the fimA promoter [1].

References

  1. Construction and characterization of a fimZ mutant of Salmonella typhimurium. Yeh, K.S., Hancox, L.S., Clegg, S. J. Bacteriol. (1995) [Pubmed]
 
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