Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

fliK - flagellar hook-length control protein FliK

Salmonella enterica subsp. enterica serovar Typhimurium str. LT2

Muramoto, K. et al., Ohnishi, K. et al., Koroyasu, S. et al., Williams, A.W. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of fliK

Frameshift mutations in the fliK gene of Salmonella result in abnormal elongation of the hook and the failure to assemble filament (polyhook phenotype) [1].

High impact information on fliK

Conversely, underexpression of the wild-type fliK gene, achieved by changing the sole Trp codon in the sequence (Trp271) to UGA, decreased both the number of flagella and the ability to swarm [1].
Second mutations in either the fliK or flhB genes, as found in pseudorevertants from fliK mutants, give rise to polyhook filaments (phf) [2].
Mutations in fliK and flhB affecting flagellar hook and filament assembly in Salmonella typhimurium [3].
When culture media were analyzed for the presence of hook protein, it was found only with the flgD mutant and, in smaller amounts, the fliK (polyhook) mutant [4].

References

Effect of cellular level of FliK on flagellar hook and filament assembly in Salmonella typhimurium. Muramoto, K., Makishima, S., Aizawa, S.I., Macnab, R.M. J. Mol. Biol. (1998) [Pubmed]
Kinetic analysis of the growth rate of the flagellar hook in Salmonella typhimurium by the population balance method. Koroyasu, S., Yamazato, M., Hirano, T., Aizawa, S.I. Biophys. J. (1998) [Pubmed]
Mutations in fliK and flhB affecting flagellar hook and filament assembly in Salmonella typhimurium. Williams, A.W., Yamaguchi, S., Togashi, F., Aizawa, S.I., Kawagishi, I., Macnab, R.M. J. Bacteriol. (1996) [Pubmed]
FlgD is a scaffolding protein needed for flagellar hook assembly in Salmonella typhimurium. Ohnishi, K., Ohto, Y., Aizawa, S., Macnab, R.M., Iino, T. J. Bacteriol. (1994) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.