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Gene Review

fliM  -  flagellar motor switch protein FliM

Salmonella enterica subsp. enterica serovar Typhimurium str. LT2

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Disease relevance of fliM

  • Consistent with the flagellin-TLR5 hypothesis, an aflagellar Salmonella enterica serovar Typhimurium fliM mutant exhibited an enhanced ability to establish systemic infection [1].

High impact information on fliM


  1. Identification and functional characterization of chicken toll-like receptor 5 reveals a fundamental role in the biology of infection with Salmonella enterica serovar typhimurium. Iqbal, M., Philbin, V.J., Withanage, G.S., Wigley, P., Beal, R.K., Goodchild, M.J., Barrow, P., McConnell, I., Maskell, D.J., Young, J., Bumstead, N., Boyd, Y., Smith, A.L. Infect. Immun. (2005) [Pubmed]
  2. Structural effects of mutations in Salmonella typhimurium flagellar switch complex. Zhao, R., Schuster, S.C., Khan, S. J. Mol. Biol. (1995) [Pubmed]
  3. An extreme clockwise switch bias mutation in fliG of Salmonella typhimurium and its suppression by slow-motile mutations in motA and motB. Togashi, F., Yamaguchi, S., Kihara, M., Aizawa, S.I., Macnab, R.M. J. Bacteriol. (1997) [Pubmed]
  4. Analysis of a FliM-FliN flagellar switch fusion mutant of Salmonella typhimurium. Kihara, M., Francis, N.R., DeRosier, D.J., Macnab, R.M. J. Bacteriol. (1996) [Pubmed]
  5. Molecular analysis of the flagellar switch protein FliM of Salmonella typhimurium. Sockett, H., Yamaguchi, S., Kihara, M., Irikura, V.M., Macnab, R.M. J. Bacteriol. (1992) [Pubmed]
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