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Gene Review:

fliM - flagellar motor switch protein FliM

Salmonella enterica subsp. enterica serovar Typhimurium str. LT2

Iqbal, M. et al., Togashi, F. et al., Zhao, R. et al., Kihara, M. et al., Sockett, H. et al.

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Disease relevance of fliM

Consistent with the flagellin-TLR5 hypothesis, an aflagellar Salmonella enterica serovar Typhimurium fliM mutant exhibited an enhanced ability to establish systemic infection [1].

High impact information on fliM

We have examined basal body preparations from non-motile or non-chemotactic fliG, fliM and fliN mutant strains by electron microscopy and immunoblot gel analysis [2].
Pseudorevertants (second-site suppressor mutants) were isolated from a set of parental mutants of Salmonella with defects in the flagellar switch genes fliG and fliM [3].
This sequence lies just before the 3' end of the coding sequence of the upstream fliM switch gene, in the same operon [4].
Among the three known switch genes, fliM contributes most examples of such suppressor mutations [5].

References

Identification and functional characterization of chicken toll-like receptor 5 reveals a fundamental role in the biology of infection with Salmonella enterica serovar typhimurium. Iqbal, M., Philbin, V.J., Withanage, G.S., Wigley, P., Beal, R.K., Goodchild, M.J., Barrow, P., McConnell, I., Maskell, D.J., Young, J., Bumstead, N., Boyd, Y., Smith, A.L. Infect. Immun. (2005) [Pubmed]
Structural effects of mutations in Salmonella typhimurium flagellar switch complex. Zhao, R., Schuster, S.C., Khan, S. J. Mol. Biol. (1995) [Pubmed]
An extreme clockwise switch bias mutation in fliG of Salmonella typhimurium and its suppression by slow-motile mutations in motA and motB. Togashi, F., Yamaguchi, S., Kihara, M., Aizawa, S.I., Macnab, R.M. J. Bacteriol. (1997) [Pubmed]
Analysis of a FliM-FliN flagellar switch fusion mutant of Salmonella typhimurium. Kihara, M., Francis, N.R., DeRosier, D.J., Macnab, R.M. J. Bacteriol. (1996) [Pubmed]
Molecular analysis of the flagellar switch protein FliM of Salmonella typhimurium. Sockett, H., Yamaguchi, S., Kihara, M., Irikura, V.M., Macnab, R.M. J. Bacteriol. (1992) [Pubmed]

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