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Gene Review: 

pheA  -  bifunctional chorismate mutase/prephenate...

Salmonella enterica subsp. enterica serovar Typhimurium str. LT2

 
 
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Disease relevance of pheA

  • The tct (tricarboxylate transport) locus of Salmonella typhimurium is found at 59 units between nalB and pheA (Somers et al. 1981) [1].
 

High impact information on pheA

  • The suppressor strains have only a portion of the normal level of the pheA or tyrA enzyme activity and thus experience a partial limitation in the synthesis of phenylalanine or tyrosine [2].
  • In addition the hyd and recA loci were located establishing the gene order in this region of the chromosome as: pheA tct nalB recA srlA hyd cys [3].
  • Using a series of tct::Tn10 directed Hfrs the tct locus was accurately positioned at 59 units between srlA and pheA, but was not cotransducible with either gene [3].
 

Biological context of pheA

  • Such suppressor mutations were obtained directly by mutation of the wild-type pheA gene as well as indirectly by partial reversion of a variety of nonleaky pheA and tyrA mutations [2].

References

  1. Genetic fine structure of the tricarboxylate transport (tct) locus of Salmonella typhimurium. Somers, J.M., Kay, W.W. Mol. Gen. Genet. (1983) [Pubmed]
  2. Suppression of a deletion mutation in the glutamine amidotransferase region of the Salmonella typhimurium trpD gene by mutations in pheA and tyrA. Tanemura, S., Bauerle, R. J. Bacteriol. (1979) [Pubmed]
  3. Flurorcitrate resistant tricarboxylate transport mutants of Salmonella typhimurium. Somers, J.M., Sweet, G.D., Kay, W.W. Mol. Gen. Genet. (1981) [Pubmed]
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