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Gene Review

sopD  -  secreted effector protein SopD

Salmonella enterica subsp. enterica serovar Typhimurium str. LT2

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Disease relevance of sopD

  • Salmonella enterica serovar Typhimurium (S. Typhimurium) mutants lacking either sopD or sopD2 were attenuated for replication in the spleens of infected mice when competed against wild-type bacteria in mixed infection experiments [1].

High impact information on sopD

  • However, a contribution of sopA or sopD to invasion was not apparent when invasion assays were performed with the nonpolarized colon carcinoma cell lines T84 and HT-29 [2].


  1. The related effector proteins SopD and SopD2 from Salmonella enterica serovar Typhimurium contribute to virulence during systemic infection of mice. Jiang, X., Rossanese, O.W., Brown, N.F., Kujat-Choy, S., Galán, J.E., Finlay, B.B., Brumell, J.H. Mol. Microbiol. (2004) [Pubmed]
  2. SipA, SopA, SopB, SopD, and SopE2 contribute to Salmonella enterica serotype typhimurium invasion of epithelial cells. Raffatellu, M., Wilson, R.P., Chessa, D., Andrews-Polymenis, H., Tran, Q.T., Lawhon, S., Khare, S., Adams, L.G., Bäumler, A.J. Infect. Immun. (2005) [Pubmed]
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