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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

Spleen

 
 
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Disease relevance of Spleen

  • In vivo, IL-12 production was induced in spleens of immunocompetent mice early during M. bovis BCG infection but not in those of mutant mice lacking the receptors for IFN-gamma or TNF [1].
  • Infectious MuLV was invariably recovered from spleens cultured from mice with p30 antigenemia, which was present in all mice that developed lymphoma [2].
  • Nevertheless, the CFU-S from MPSV-infected animals differentiated normally in the spleens of irradiated, normal recipient mice (except for some hyperplasia of the erythroid component of spleen colonies) [3].
  • After infecting these mice with N-tropic FV complex, we followed the replication of spleen focus-forming virus (SFFV) and the generation of SFFV-transformed tumor colony-forming cells (CFC) in their spleens [4].
  • Lymphocytes from the spleens and thymuses of leukemic animals were examined for Thy-1 antigen and immunoglobulins on the cell surface; all the leukemias were composed of T- cells and/or nonreactive cells lacking both the Thy-1 antigen and immunoglobulins [5].
 

Psychiatry related information on Spleen

 

High impact information on Spleen

  • TWEAK-/- mice developed oversized spleens with expanded memory and T helper 1 (TH1) subtype cells upon aging and mounted stronger innate and adaptive TH1-based responses against tumor challenge [8].
  • These H2-c-fos mice have enlarged spleens and hyperplastic thymuses containing an increased number of thymic epithelial cells [9].
  • Antagonizing RAGE suppressed cell stress and amyloid deposition in mouse spleens [10].
  • Prion titres were undetectable in spleens of inoculated Prnp(o/o) mice, but were restored to wild-type levels upon reconstitution of the host lymphohaemopoietic system with PrP-expressing cells [11].
  • Friend murine erythroleukaemia (F-MEL) cells are a permanent line of primitive erythroid precursors originally derived from the spleens of mice infected with the Friend strain of murine leukaemia virus [12].
 

Chemical compound and disease context of Spleen

 

Biological context of Spleen

 

Anatomical context of Spleen

 

Associations of Spleen with chemical compounds

  • Here, we demonstrate by immunolocalization experiments and flow cytometric analysis that, contrary to expectation, DC and not MPhi are the initial cells to synthesize IL-12 in the spleens of mice exposed in vivo to an extract of Toxoplasma gondii or to lipopolysaccharide, two well characterized microbial stimulants of the cytokine [28].
  • Because fetal DNP precursors from spleens and livers that had been incubated in organ culture resulted in a greater proportion of clones secreting IgG compared with age-matched uncultured controls, it was concluded that the maturation with regard to the ability to secrete IgG can occur in vitro [18].
  • BALB/cB cells specific for 2,4,6-trinitrophenyl (TNP) were isolated from spleens of immune mice by elution from TNP-gelatin-coated dishes [29].
  • Although cholesterol-rich spur cells are further modified in the circulation of patients with spleens, this abnormality of the membrane lipid bilayer, induced by cholesterol-rich cholesterol-lecithin dispersions, represents the primary spur cell defect [30].
  • However, 7 days following 5-aza-2'-deoxycytidine treatment, the incorporation of dThd into DNA in the spleens of mice was significantly increased [31].
 

Gene context of Spleen

  • We found that IL-10-specific mRNA was produced in the spleens of mice with acute T. cruzi infections [32].
  • Cells harvested from spleens of mice injected with anti-CD3 90 min earlier secreted IL-4, IL-2, and IFN-gamma without further stimulation [33].
  • T lymphocytes were the major source of interferon gamma, whereas non-B/non-T cells were the dominant source of IL-4 and IL-6 in the spleens of immunized animals [34].
  • When lymphocyte colonies derived from a single cell were pooled and individually injected into scid mice, donor-type IgM was measurable in the serum of mice and spleens contained donor-type B cells [35].
  • Increased cycling status of CCR2 (-/-) BM MPC did not result in increased numbers of nucleated cells or MPC in BM or spleens of CCR2 (-/-) mice [36].
 

Analytical, diagnostic and therapeutic context of Spleen

References

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  2. Transmission of murine leukemia virus (Scripps) from parent to progeny mice: a comparison of assay systems. Jenson, A.B., Groff, D.E., McConahey, P.J., Dixon, F.J. J. Natl. Cancer Inst. (1976) [Pubmed]
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  14. Systemic gene therapy of murine melanoma using tissue specific expression of the HSVtk gene involves an immune component. Vile, R.G., Nelson, J.A., Castleden, S., Chong, H., Hart, I.R. Cancer Res. (1994) [Pubmed]
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  16. Granuloma formation in severe combined immunodeficient (SCID) mice in response to progressive BCG infection. Tendency not to form granulomas in the lung is associated with faster bacterial growth in this organ. North, R.J., Izzo, A.A. Am. J. Pathol. (1993) [Pubmed]
  17. Enzymic differentiation of neurologic and nonneurologic forms of Gaucher's disease. Glew, R.H., Daniels, L.B., Clark, L.S., Hoyer, S.W. J. Neuropathol. Exp. Neurol. (1982) [Pubmed]
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  20. A model for spontaneous B-lineage lymphomas in IgHmu-HOX11 transgenic mice. Hough, M.R., Reis, M.D., Singaraja, R., Bryce, D.M., Kamel-Reid, S., Dardick, I., Breitman, M.L., Dubé, I.D. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  21. Host-pathogen interactions: Host resistance factor Nramp1 up-regulates the expression of Salmonella pathogenicity island-2 virulence genes. Zaharik, M.L., Vallance, B.A., Puente, J.L., Gros, P., Finlay, B.B. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  22. Inhibition of murine erythroid colony formation in vitro by interferon gamma and correction by interferon receptor immunoadhesin. Means, R.T., Krantz, S.B., Luna, J., Marsters, S.A., Ashkenazi, A. Blood (1994) [Pubmed]
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