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Gene Review:

uspA - universal stress protein A

Salmonella enterica subsp. enterica serovar Typhimurium str. LT2

Liu, W.T. et al.

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Disease relevance of uspA

Role of the universal stress protein UspA of Salmonella in growth arrest, stress and virulence [1].

High impact information on uspA

Inactivation of uspA in S. typhimurium C5, lead to increased susceptibility to stress conditions [1].
An in silico screen of the Salmonella genome sequence revealed that Salmonella typhimurium LT2 possesses a homologue belonging to the universal stress protein A (UspA) family [1].
Furthermore, UspA makes an important contribution to the in vivo virulence of Salmonella in mice thus highlighting the importance of stress resistance regulation in pathogenicity and survival within the host [1].

References

Role of the universal stress protein UspA of Salmonella in growth arrest, stress and virulence. Liu, W.T., Karavolos, M.H., Bulmer, D.M., Allaoui, A., Hormaeche, R.D., Lee, J.J., Anjam Khan, C.M. Microb. Pathog. (2007) [Pubmed]

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