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Gene Review

ilvC  -  ketol-acid reductoisomerase

Salmonella enterica subsp. enterica serovar Typhimurium str. LT2

 
 
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High impact information on ilvC

  • One inhibitor was the sulfonylurea herbicide sulfometuron methyl (SMM), which inhibits this isozyme and AHAS of other organisms, and the other was N-isopropyl oxalylhydroxamate (IpOHA), which inhibits ketol-acid reductoisomerase (KARI) [1].
  • IpOHA has strong initial effects at lower concentrations than does SMM and leads to increases both in the acetohydroxy acid substrates of KARI and, surprisingly, in ketobutyrate [1].
  • The mutations are in a polycistronic operon transcribed in the order ilvGEDA and in a monocistronic operon ilvC [2].

References

 
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