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Gene Review:

frd - product is methyl donor used by dTMP synthase

Enterobacteria phage T4

Kreuzer, K.N. et al., Ruckman, J. et al., Wang, Y. et al.

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Disease relevance of frd

Analysis of T4 bacteriophage deletion mutants that lack td and frd genes [1].

High impact information on frd

For these experiments, we generated a novel phage strain that cleaves its own genome within the nonessential frd gene by means of the I-TevI endonuclease (encoded within the intron of the wild-type td gene) [2].
We have identified additional sites of processing within several other ribosome binding sites, including two sites in the polycistronic frd transcript [3].

References

Analysis of T4 bacteriophage deletion mutants that lack td and frd genes. Wang, Y., Mathews, C.K. J. Virol. (1989) [Pubmed]
Recombination-dependent DNA replication stimulated by double-strand breaks in bacteriophage T4. Kreuzer, K.N., Saunders, M., Weislo, L.J., Kreuzer, H.W. J. Bacteriol. (1995) [Pubmed]
Identification of a T4 gene required for bacteriophage mRNA processing. Ruckman, J., Parma, D., Tuerk, C., Hall, D.H., Gold, L. New Biol. (1989) [Pubmed]

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