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Gene Review

denA  -  site-specific endonuclease II (EndoII)...

Enterobacteria phage T4

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Disease relevance of denA

  • The 136 codon (408 bp) denA gene encoding endonuclease II (Endoll) of bacteriophage T4 was unambiguously identified through sequencing and subsequent cloning [1].
  • An E. coli B Tab strain, EM121, was isolated that restricts T4 denA (DNA endonuclease II) mutants at 37 degrees C and above, but is permissive for wild-type T4 at all temperatures examined [2].

High impact information on denA

  • However, neither plasmid or chromosomal degradation can be detected in denA mutant infections by the method of DNA--DNA hybridization on nitrocellulose filters [3].
  • DNA fragments from a BglII digestion of cytosine-containing DNA from a T4 dCTPase- denA denB(rIIH23B) alc mutant were hybridized with full-length chromosomal strands of bacteriophage T2, and the heteroduplexes were examined by electron microscopy [4].
  • Bacteriophage T4 DNA containing cytosine has been obtained from cells infected with phage mutant in genes 42, 56, denA and denB [5].


  1. Sequence-specific cleavage by bacteriophage T4 endonuclease II in vitro. Carlson, K., Kosturko, L.D., Nyström, A.C. Mol. Microbiol. (1999) [Pubmed]
  2. An E. coli B mutation, rpoB5081, that prevents growth of phage T4 strains defective in host DNA degradation. Miller, E.S., Shih, G.C., Chang, S.K., Ballard, D.N. FEMS Microbiol. Lett. (1997) [Pubmed]
  3. Fate of cloned bacteriophage T4 DNA after phage T4 infection of clone-bearing cells. Mattson, T., Van Houwe, G., Bolle, A., Epstein, R. J. Mol. Biol. (1983) [Pubmed]
  4. Alignment of a restriction map with the genetic map of bacteriophage T4. Yee, J.K., Marsh, R.C. J. Virol. (1981) [Pubmed]
  5. Genetic identification of cloned fragments of bacteriophage T4 DNA and complementation by some clones containing early T4 genes. Mattson, T., Van Houwe, G., Bolle, A., Selzer, G., Epstein, R. Mol. Gen. Genet. (1977) [Pubmed]
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