Disease relevance of KU1_3

• RNA phage KU1 has an insertion of 18 nucleotides in the start codon of its lysis gene [1].
• We also show that analogous to the group I phages, such as MS2 and fr, expression of the lysis gene in KU1 and JP34 is coupled to termination of translation at the coat gene [1].
• Various morphological aspects of Escherichia coli lysis by two distinct RNA bacteriophages [2].

High impact information on KU1_3

• This suggests that the ribosomes completing the coat gene translation are exclusively responsible for translation of the lysis gene [3].
• Some balloon-like structures also appeared on the surfaces of cells induced by the cloned lysis gene of RNA phage SP and material also appeared to be leaking through the cell wall in the photographs [2].

Anatomical context of KU1_3

• Cells induced by the GA lysis gene showed many ballooning structures on the cell surfaces and others leaked material through the cell wall [2].

References