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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Cfl2  -  cofilin 2, muscle

Mus musculus

Synonyms: Cofilin, muscle isoform, Cofilin-2
 
 
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High impact information on Cfl2

  • Stretch stimulated Rho activity and phosphorylation of the actin-severing protein cofilin-2, although both effects were slow in onset (Rho-GTP, >15 min; cofilin-P, >1 h) [1].
  • Cofilin-2 is expressed in muscle cells and ADF is restricted to epithelia and endothelia [2].
  • The muscle-specific cofilin-2 has a weaker actin filament depolymerization activity and displays a 5-10-fold higher affinity for ATP-actin monomers than cofilin-1 and ADF [2].
 

Biological context of Cfl2

References

  1. Stretch of the vascular wall induces smooth muscle differentiation by promoting actin polymerization. Albinsson, S., Nordström, I., Hellstrand, P. J. Biol. Chem. (2004) [Pubmed]
  2. The three mouse actin-depolymerizing factor/cofilins evolved to fulfill cell-type-specific requirements for actin dynamics. Vartiainen, M.K., Mustonen, T., Mattila, P.K., Ojala, P.J., Thesleff, I., Partanen, J., Lappalainen, P. Mol. Biol. Cell (2002) [Pubmed]
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