Chemical Compound Review:
SureCN1165652 4-(1-aminoethyl)-N-pyridin-4- yl...
Synonyms:
SureCN1554110, Y0503_SIGMA, AC1L3XFM, LS-173023, EU-0100333, ...
This record was replaced with 5711.
- Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension. Uehata, M., Ishizaki, T., Satoh, H., Ono, T., Kawahara, T., Morishita, T., Tamakawa, H., Yamagami, K., Inui, J., Maekawa, M., Narumiya, S. Nature (1997)
- Activation of G12/G13 results in shape change and Rho/Rho-kinase-mediated myosin light chain phosphorylation in mouse platelets. Klages, B., Brandt, U., Simon, M.I., Schultz, G., Offermanns, S. J. Cell Biol. (1999)
- Ephrin-A5 induces collapse of growth cones by activating Rho and Rho kinase. Wahl, S., Barth, H., Ciossek, T., Aktories, K., Mueller, B.K. J. Cell Biol. (2000)
- Inhibition of Rho-kinase affects astrocytoma morphology, motility, and invasion through activation of Rac1. Salhia, B., Rutten, F., Nakada, M., Beaudry, C., Berens, M., Kwan, A., Rutka, J.T. Cancer Res. (2005)
- Inhibition of intrahepatic metastasis of human hepatocellular carcinoma by Rho-associated protein kinase inhibitor Y-27632. Takamura, M., Sakamoto, M., Genda, T., Ichida, T., Asakura, H., Hirohashi, S. Hepatology (2001)
- Effect of doxazosin with and without rho-kinase inhibitor on human corpus cavernosum smooth muscle in the presence of bladder outlet obstruction. Demir, O., Murat, N., Aslan, G., Gidener, S., Esen, A.A. J. Urol. (2006)
- Nonsteroidal anti-inflammatory drugs can lower amyloidogenic Abeta42 by inhibiting Rho. Zhou, Y., Su, Y., Li, B., Liu, F., Ryder, J.W., Wu, X., Gonzalez-DeWhitt, P.A., Gelfanova, V., Hale, J.E., May, P.C., Paul, S.M., Ni, B. Science (2003)
- Antagonism of Rho-kinase stimulates rat penile erection via a nitric oxide-independent pathway. Chitaley, K., Wingard, C.J., Clinton Webb, R., Branam, H., Stopper, V.S., Lewis, R.W., Mills, T.M. Nat. Med. (2001)
- Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase. Maekawa, M., Ishizaki, T., Boku, S., Watanabe, N., Fujita, A., Iwamatsu, A., Obinata, T., Ohashi, K., Mizuno, K., Narumiya, S. Science (1999)
- Defective RhoA/Rho-kinase signaling contributes to vascular hypocontractility and vasodilation in cirrhotic rats. Hennenberg, M., Biecker, E., Trebicka, J., Jochem, K., Zhou, Q., Schmidt, M., Jakobs, K.H., Sauerbruch, T., Heller, J. Gastroenterology (2006)
- Functional selectivity of G protein signaling by agonist peptides and thrombin for the protease-activated receptor-1. McLaughlin, J.N., Shen, L., Holinstat, M., Brooks, J.D., Dibenedetto, E., Hamm, H.E. J. Biol. Chem. (2005)
- Mechanical stress increases RhoA activation in airway smooth muscle cells. Smith, P.G., Roy, C., Zhang, Y.N., Chauduri, S. Am. J. Respir. Cell Mol. Biol. (2003)
- A selective ROCK inhibitor, Y27632, prevents dimethylnitrosamine-induced hepatic fibrosis in rats. Tada, S., Iwamoto, H., Nakamuta, M., Sugimoto, R., Enjoji, M., Nakashima, Y., Nawata, H. J. Hepatol. (2001)
- Statins revert doxorubicin resistance via nitric oxide in malignant mesothelioma. Riganti, C., Orecchia, S., Pescarmona, G., Betta, P.G., Ghigo, D., Bosia, A. Int. J. Cancer (2006)
- Expression of Rho-kinase (ROCK-1 and ROCK-2) and its substantial role in the contractile activity of the sheep ureter. Levent, A., Büyükafsar, K. Br. J. Pharmacol. (2004)
- Rho kinase blockade prevents inflammation via nuclear factor kappa B inhibition: evidence in Crohn's disease and experimental colitis. Segain, J.P., Raingeard de la Blétière, D., Sauzeau, V., Bourreille, A., Hilaret, G., Cario-Toumaniantz, C., Pacaud, P., Galmiche, J.P., Loirand, G. Gastroenterology (2003)
- Role of Rho-associated kinase in neointima formation after vascular injury. Shibata, R., Kai, H., Seki, Y., Kato, S., Morimatsu, M., Kaibuchi, K., Imaizumi, T. Circulation (2001)
- E1AF/PEA3 activates the Rho/Rho-associated kinase pathway to increase the malignancy potential of non-small-cell lung cancer cells. Hakuma, N., Kinoshita, I., Shimizu, Y., Yamazaki, K., Yoshida, K., Nishimura, M., Dosaka-Akita, H. Cancer Res. (2005)
- The COOH-terminal end of R-Ras alters the motility and morphology of breast epithelial cells through Rho/Rho-kinase. Jeong, H.W., Nam, J.O., Kim, I.S. Cancer Res. (2005)
- Rho kinases play an obligatory role in vertebrate embryonic organogenesis. Wei, L., Roberts, W., Wang, L., Yamada, M., Zhang, S., Zhao, Z., Rivkees, S.A., Schwartz, R.J., Imanaka-Yoshida, K. Development (2001)
- Rho kinase regulates tight junction function and is necessary for tight junction assembly in polarized intestinal epithelia. Walsh, S.V., Hopkins, A.M., Chen, J., Narumiya, S., Parkos, C.A., Nusrat, A. Gastroenterology (2001)
- Molecular dissection of the Rho-associated protein kinase (p160ROCK)-regulated neurite remodeling in neuroblastoma N1E-115 cells. Hirose, M., Ishizaki, T., Watanabe, N., Uehata, M., Kranenburg, O., Moolenaar, W.H., Matsumura, F., Maekawa, M., Bito, H., Narumiya, S. J. Cell Biol. (1998)
- Effects of cell tension on the small GTPase Rac. Katsumi, A., Milanini, J., Kiosses, W.B., del Pozo, M.A., Kaunas, R., Chien, S., Hahn, K.M., Schwartz, M.A. J. Cell Biol. (2002)
- Cooperative effects of Rho and mechanical stretch on stress fiber organization. Kaunas, R., Nguyen, P., Usami, S., Chien, S. Proc. Natl. Acad. Sci. U.S.A. (2005)
- p160ROCK mediates RhoA activation of Na-H exchange. Tominaga, T., Ishizaki, T., Narumiya, S., Barber, D.L. EMBO J. (1998)
- Dominant role of smooth muscle L-type calcium channel Cav1.2 for blood pressure regulation. Moosmang, S., Schulla, V., Welling, A., Feil, R., Feil, S., Wegener, J.W., Hofmann, F., Klugbauer, N. EMBO J. (2003)
- Agonist-induced regulation of myosin phosphatase activity in human platelets through activation of Rho-kinase. Suzuki, Y., Yamamoto, M., Wada, H., Ito, M., Nakano, T., Sasaki, Y., Narumiya, S., Shiku, H., Nishikawa, M. Blood (1999)
- The G protein-coupled receptor S1P2 regulates Rho/Rho kinase pathway to inhibit tumor cell migration. Lepley, D., Paik, J.H., Hla, T., Ferrer, F. Cancer Res. (2005)
- Regulation of tight junction permeability and occludin phosphorylation by Rhoa-p160ROCK-dependent and -independent mechanisms. Hirase, T., Kawashima, S., Wong, E.Y., Ueyama, T., Rikitake, Y., Tsukita, S., Yokoyama, M., Staddon, J.M. J. Biol. Chem. (2001)
- RhoA/ROCK signaling regulates Sox9 expression and actin organization during chondrogenesis. Woods, A., Wang, G., Beier, F. J. Biol. Chem. (2005)
- The functional role of rho and rho-associated coiled-coil forming protein kinase in eotaxin signaling of eosinophils. Adachi, T., Vita, R., Sannohe, S., Stafford, S., Alam, R., Kayaba, H., Chihara, J. J. Immunol. (2001)
- Effects of Peripheral Cannabinoid Receptor Ligands on Motility and Polarization in Neutrophil-like HL60 Cells and Human Neutrophils. Kurihara, R., Tohyama, Y., Matsusaka, S., Naruse, H., Kinoshita, E., Tsujioka, T., Katsumata, Y., Yamamura, H. J. Biol. Chem. (2006)
- RhoA modulates Smad signaling during transforming growth factor-beta-induced smooth muscle differentiation. Chen, S., Crawford, M., Day, R.M., Briones, V.R., Leader, J.E., Jose, P.A., Lechleider, R.J. J. Biol. Chem. (2006)
- Cell type-specific regulation of RhoA activity during cytokinesis. Yoshizaki, H., Ohba, Y., Parrini, M.C., Dulyaninova, N.G., Bresnick, A.R., Mochizuki, N., Matsuda, M. J. Biol. Chem. (2004)
- Rho kinase: a target for treating urinary bladder dysfunction? Peters, S.L., Schmidt, M., Michel, M.C. Trends Pharmacol. Sci. (2006)
- Intrahepatic upregulation of RhoA and Rho-kinase signalling contributes to increased hepatic vascular resistance in rats with secondary biliary cirrhosis. Zhou, Q., Hennenberg, M., Trebicka, J., Jochem, K., Leifeld, L., Biecker, E., Sauerbruch, T., Heller, J. Gut (2006)