Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

clf2 - cleft lip 2

Mus musculus

Juriloff, D.M. et al., Juriloff, D.M. et al.

Juriloff, Harris, McMahon, Carroll, Lidral, Juriloff, Harris, Brown,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of clf2

Specific combinations of marker genotypes associated with cleft lip risk indicated that high risk in A/WySnJ mice is caused by epistatic interaction between clf1 and clf2 in the context of a genetic maternal effect [1].

High impact information on clf2

Human homologs of clf1 and clf2 are expected to be on 17q and 5q/9q [1].
The clf2 locus was newly mapped to Chromosome (Chr) 13 by a genome screen of BC1 segregants, and further defined to a 4-cM region between D13Mit13/54 and D13Mit231 by strain distribution patterns of cleft lip liability and markers in testcrossed RI strains [1].
Genotypes for a second unlinked modifier locus from A/WySn, clf2, were similarly obtained [2].
The clf2 modifier gene was found to have 3 alleles segregating in this study and to strongly influence the penetrance of CL in the compound mutant [2].

References

Unravelling the complex genetics of cleft lip in the mouse model. Juriloff, D.M., Harris, M.J., Brown, C.J. Mamm. Genome (2001) [Pubmed]
Wnt9b is the mutated gene involved in multifactorial nonsyndromic cleft lip with or without cleft palate in A/WySn mice, as confirmed by a genetic complementation test. Juriloff, D.M., Harris, M.J., McMahon, A.P., Carroll, T.J., Lidral, A.C. Birth Defects Res. Part A Clin. Mol. Teratol. (2006) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.