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Gene Review

SPATA17  -  spermatogenesis associated 17

Homo sapiens

Synonyms: IQCH, MSRG-11, MSRG11, Spermatogenesis-associated protein 17
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Disease relevance of SPATA17

  • In an experimental unilateral cryptorchidism model of an adult mouse, the expression of Spata17 mRNA had no obvious difference with the normal testis until postoperation day 1, but gradually decreased from day 3 and was almost undetectable on day 17 [1].

High impact information on SPATA17

  • Immunohistochemical analysis revealed that Spata17 protein was most abundant in the cytoplasm of round spermatids and elongating spermatids within seminiferous tubules of the adult testis [1].
  • In this study, anti-spermatogenesis-associated 17 (Spata17) polyclonal antibody was prepared by immunizing New Zealand white rabbits with a synthesized peptide corresponding to the amino acid sequence 7-23 of the mouse Spata17 protein [1].


  1. Expression and identification of a novel apoptosis gene Spata17 (MSRG-11) in mouse spermatogenic cells. Deng, Y., Hu, L.S., Lu, G.X. Acta Biochim. Biophys. Sin. (Shanghai) (2006) [Pubmed]
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