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MeSH Review

Seminiferous Tubules

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Disease relevance of Seminiferous Tubules

  • However, premeiotic murine gametocytes lacked detectable Gas8 protein, as did seminiferous tubules in biopsy specimens from seven human males having cytological evidence of non-obstructive azoospermia secondary to Sertoli cell-only syndrome [1].
  • Microscopic changes were restricted to the testes and the heart, and were seen only in males dosed with 1080 at 0.25 mg/kg/day and included severe hypospermia in the epididymides, severe degeneration of the seminiferous tubules of the testes, and cardiomyopathy [2].
  • TP was given for 14 days (3 mg/100 g body weight, i.m.) to assess the acute effects of testosterone on the seminiferous tubules [3].
  • Histopathological studies revealed marked degeneration of seminiferous tubules and lumen devoid of sperms, further confirming testicular toxicity of styrene [4].
  • Other changes seen were the hyalinization of gastric submucosal wall, generalized testicular atrophy due to the loss of seminiferous tubules, coagulation necrosis of intestinal mucosal wall, hyperpigmentation, and more advanced and severe chronic progressive glomerulonephropathy in the TFE-treated rats [5].

High impact information on Seminiferous Tubules


Chemical compound and disease context of Seminiferous Tubules


Biological context of Seminiferous Tubules


Anatomical context of Seminiferous Tubules


Associations of Seminiferous Tubules with chemical compounds


Gene context of Seminiferous Tubules


Analytical, diagnostic and therapeutic context of Seminiferous Tubules


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  2. A 90-day toxicological evaluation of Compound 1080 (sodium monofluoroacetate) in Sprague-Dawley rats. Eason, C.T., Turck, P. Toxicol. Sci. (2002) [Pubmed]
  3. Effects of high doses of testosterone propionate and testosterone enanthate on rat seminiferous tubules--a stereological and cytological study. Jezek, D., Simunić-Banek, L., Pezerović-Panijan, R. Arch. Toxicol. (1993) [Pubmed]
  4. Effect of styrene administration on rat testis. Srivastava, S., Seth, P.K., Srivastava, S.P. Arch. Toxicol. (1989) [Pubmed]
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  7. Postnatal sex reversal of the ovaries in mice lacking estrogen receptors alpha and beta. Couse, J.F., Hewitt, S.C., Bunch, D.O., Sar, M., Walker, V.R., Davis, B.J., Korach, K.S. Science (1999) [Pubmed]
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  14. Toxicity study of di(2-ethylhexyl)phthalate (DEHP) in combination with acetone in rats. Dalgaard, M., Ostergaard, G., Lam, H.R., Hansen, E.V., Ladefoged, O. Pharmacol. Toxicol. (2000) [Pubmed]
  15. Testicular peritubular cells secrete a protein under androgen control that modulates Sertoli cell functions. Skinner, M.K., Fritz, I.B. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  16. Disruption of spermatogenic cell adhesion and male infertility in mice lacking TSLC1/IGSF4, an immunoglobulin superfamily cell adhesion molecule. Yamada, D., Yoshida, M., Williams, Y.N., Fukami, T., Kikuchi, S., Masuda, M., Maruyama, T., Ohta, T., Nakae, D., Maekawa, A., Kitamura, T., Murakami, Y. Mol. Cell. Biol. (2006) [Pubmed]
  17. CCR4-associated factor CAF1 is an essential factor for spermatogenesis. Berthet, C., Morera, A.M., Asensio, M.J., Chauvin, M.A., Morel, A.P., Dijoud, F., Magaud, J.P., Durand, P., Rouault, J.P. Mol. Cell. Biol. (2004) [Pubmed]
  18. Targeted disruption of CDK4 delays cell cycle entry with enhanced p27(Kip1) activity. Tsutsui, T., Hesabi, B., Moons, D.S., Pandolfi, P.P., Hansel, K.S., Koff, A., Kiyokawa, H. Mol. Cell. Biol. (1999) [Pubmed]
  19. Alternative exon splicing controls a translational switch from activator to repressor isoforms of transcription factor CREB during spermatogenesis. Walker, W.H., Girardet, C., Habener, J.F. J. Biol. Chem. (1996) [Pubmed]
  20. Cooperativity between Sertoli cells and testicular peritubular cells in the production and deposition of extracellular matrix components. Skinner, M.K., Tung, P.S., Fritz, I.B. J. Cell Biol. (1985) [Pubmed]
  21. Design of a long-acting follitropin agonist by fusing the C-terminal sequence of the chorionic gonadotropin beta subunit to the follitropin beta subunit. Fares, F.A., Suganuma, N., Nishimori, K., LaPolt, P.S., Hsueh, A.J., Boime, I. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  22. Inhibition of testicular germ cell apoptosis and differentiation in mice misexpressing Bcl-2 in spermatogonia. Furuchi, T., Masuko, K., Nishimune, Y., Obinata, M., Matsui, Y. Development (1996) [Pubmed]
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  25. The testicular antiviral defense system: localization, expression, and regulation of 2'5' oligoadenylate synthetase, double-stranded RNA-activated protein kinase, and Mx proteins in the rat seminiferous tubule. Dejucq, N., Chousterman, S., Jégou, B. J. Cell Biol. (1997) [Pubmed]
  26. Development of a Mn-2+-sensitive, "soluble" adenylate cyclase in rat testis. Braun, T., Dods, R.F. Proc. Natl. Acad. Sci. U.S.A. (1975) [Pubmed]
  27. Characterization of mutations induced by ethylnitrosourea in seminiferous tubule germ cells of transgenic B6C3F1 mice. Provost, G.S., Short, J.M. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  28. Clinical aspects of male germ cell apoptosis during testis development and spermatogenesis. Dunkel, L., Hirvonen, V., Erkkilä, K. Cell Death Differ. (1997) [Pubmed]
  29. Effects of fractionated irradiation of endocrine aspects of testicular function. Shapiro, E., Kinsella, T.J., Makuch, R.W., Fraass, B.A., Glatstein, E., Rosenberg, S.A., Sherins, R.J. J. Clin. Oncol. (1985) [Pubmed]
  30. Cyclic expression of endothelin-converting enzyme-1 mediates the functional regulation of seminiferous tubule contraction. Tripiciano, A., Peluso, C., Morena, A.R., Palombi, F., Stefanini, M., Ziparo, E., Yanagisawa, M., Filippini, A. J. Cell Biol. (1999) [Pubmed]
  31. Dual control of seminiferous tubule contractility mediated by ETA and ETB endothelin receptor subtypes. Tripiciano, A., Palombi, F., Ziparo, E., Filippini, A. FASEB J. (1997) [Pubmed]
  32. Alternative patterns of transcription and translation of the ribosomal protein L32 mRNA in somatic and spermatogenic cells in mice. Kleene, K.C., Cataldo, L., Mastrangelo, M.A., Tagne, J.B. Exp. Cell Res. (2003) [Pubmed]
  33. Analysis of HLA class Ib gene expression in male gametogenic cells. Fiszer, D., Ulbrecht, M., Fernandez, N., Johnson, J.P., Weiss, E.H., Kurpisz, M. Eur. J. Immunol. (1997) [Pubmed]
  34. Expression and regulation of insulin-like growth factor-binding protein-1, -2, -3, and -4 messenger ribonucleic acids in purified rat Leydig cells and their biological effects. Lin, T., Wang, D., Nagpal, M.L., Shimasaki, S., Ling, N. Endocrinology (1993) [Pubmed]
  35. Developmental regulation of the thyroid hormone receptor alpha 1 mRNA expression in the rat testis. Jannini, E.A., Dolci, S., Ulisse, S., Nikodem, V.M. Mol. Endocrinol. (1994) [Pubmed]
  36. Gonadotropin-independent familial sexual precocity with premature Leydig and germinal cell maturation (familial testotoxicosis): effects of a potent luteinizing hormone-releasing factor agonist and medroxyprogesterone acetate therapy in four cases. Rosenthal, S.M., Grumbach, M.M., Kaplan, S.L. J. Clin. Endocrinol. Metab. (1983) [Pubmed]
  37. Anterior pituitary hormonal regulation of testicular gonadotropin-releasing hormone receptors. Bourne, G.A., Marshall, J.C. Endocrinology (1984) [Pubmed]
  38. Stage-specific expression of pituitary adenylate cyclase-activating polypeptide (PACAP) mRNA in the rat seminiferous tubules. Kononen, J., Paavola, M., Penttilä, T.L., Parvinen, M., Pelto-Huikko, M. Endocrinology (1994) [Pubmed]
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