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Gene Review: 

Col9a2  -  collagen, type IX, alpha 2

Mus musculus

Synonyms: AI427499, Col9a-2, Collagen alpha-2(IX) chain
 
 
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High impact information on Col9a2

  • Here we show that the deficiency in alpha1(IX) chains leads to a functional knock-out of all polypeptides of collagen IX, whereas the Col9a2 and Col9a3 genes were normally transcribed [1].
  • This was accompanied by increasing expression of nonchondrocytic Col9a1, Col9a2, and Col9a3, first detected at 11.5 dpc [2].
  • Sequence analysis of the promoter regions for the human COL9A2, the mouse Col9a2 and the human COL2A1 genes identified a conserved 14 bp sequence [3].
  • A single-strand conformational polymorphism within the murine Col9a2 gene was used to map this locus to mouse chromosome 4 [4].

References

  1. Absence of the alpha1(IX) chain leads to a functional knock-out of the entire collagen IX protein in mice. Hagg, R., Hedbom, E., Möllers, U., Aszódi, A., Fässler, R., Bruckner, P. J. Biol. Chem. (1997) [Pubmed]
  2. Type II and type IX collagen transcript isoforms are expressed during mouse testis development. McClive, P.J., Sinclair, A.H. Biol. Reprod. (2003) [Pubmed]
  3. Human COL9A1 and COL9A2 genes. Two genes of 90 and 15 kb code for similar polypeptides of the same collagen molecule. Pihlajamaa, T., Vuoristo, M.M., Annunen, S., Perälä, M., Prockop, D.J., Ala-Kokko, L. Matrix Biol. (1998) [Pubmed]
  4. The genes encoding alpha 2(IX) collagen (COL9A2) map to human chromosome 1p32.3-p33 and mouse chromosome 4. Warman, M.L., McCarthy, M.T., Perälä, M., Vuorio, E., Knoll, J.H., McDaniels, C.N., Mayne, R., Beier, D.R., Olsen, B.R. Genomics (1994) [Pubmed]
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