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Gene Review

Cryba2  -  crystallin, beta A2

Mus musculus

Synonyms: Beta-A2 crystallin, Beta-crystallin A2, E130107M19Rik
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Disease relevance of Cryba2

  • Genetic analysis revealed allelism to the Cat2 group of dominant cataracts on mouse chromosome 1; therefore, the cluster of the Cryg genes and the closely linked Cryba2 gene were tested as candidates [1].

High impact information on Cryba2

  • The candidate genes (the Cryg gene cluster and the closely linked Cryba2 gene) were sequenced [2].
  • It suggests that the cluster of gamma-crystallin encoding genes (Cryg) and the betaA2-crystallin encoding gene Cryba2 are excellent candidate genes [3].


  1. A 6-bp deletion in the Crygc gene leading to a nuclear and radial cataract in the mouse. Graw, J., Neuhäuser-Klaus, A., Löster, J., Favor, J. Invest. Ophthalmol. Vis. Sci. (2002) [Pubmed]
  2. Genetic and allelic heterogeneity of Cryg mutations in eight distinct forms of dominant cataract in the mouse. Graw, J., Neuhäuser-Klaus, A., Klopp, N., Selby, P.B., Löster, J., Favor, J. Invest. Ophthalmol. Vis. Sci. (2004) [Pubmed]
  3. Ethylnitrosourea-induced base pair substitution affects splicing of the mouse gammaE-crystallin encoding gene leading to the expression of a hybrid protein and to a cataract. Graw, J., Neuhäuser-Klaus, A., Löster, J., Klopp, N., Favor, J. Genetics (2002) [Pubmed]
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