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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

ADH6  -  alcohol dehydrogenase 6 (class V)

Homo sapiens

Synonyms: ADH-5, Alcohol dehydrogenase 6
 
 
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High impact information on ADH6

  • The data lead to the clear conclusion that a combination of the alcohol dehydrogenase 6 (ADH6) basal promoter linked to two tandem copies of an apoplipoprotein E enhancer element is the transcriptional control unit of choice for the liver-specific expression of transgenes [1].
  • The sigma-ADH exhibited 75%, 68%, and 62% sequence identity to the human class I (beta 1), II (pi), and III (chi) isoenzymes, respectively, and 61% identity to the deduced ADH6 amino acid sequence [2].
  • The full-length ADH6 cDNA was expressed in the E.coli expression system and in the in vitro translation system of rabbit reticulocytes [3].
  • The human ADH5 and rodent ADH6 seem to be the corresponding enzymes due to their similar behavior [4].
  • The newly identified ADH6 gene has hormone response elements, and it may cause the gender difference in alcoholic problems [5].
 

Other interactions of ADH6

  • The higher classes, ADH5 and ADH6, have been poorly investigated and their substrate repertoire is unknown [6].

References

  1. Chimeric transcriptional control units for improved liver-specific transgene expression. Gehrke, S., Jérôme, V., Müller, R. Gene (2003) [Pubmed]
  2. Purification and partial amino acid sequence of a high-activity human stomach alcohol dehydrogenase. Stone, C.L., Thomasson, H.R., Bosron, W.F., Li, T.K. Alcohol. Clin. Exp. Res. (1993) [Pubmed]
  3. Enzymatic properties of the protein encoded by newly cloned human alcohol dehydrogenase ADH6 gene. Chen, C.S., Yoshida, A. Biochem. Biophys. Res. Commun. (1991) [Pubmed]
  4. The mammalian alcohol dehydrogenases interact in several metabolic pathways. Höög, J.O., Strömberg, P., Hedberg, J.J., Griffiths, W.J. Chem. Biol. Interact. (2003) [Pubmed]
  5. Genetic polymorphisms of alcohol metabolizing enzymes related to alcohol sensitivity and alcoholic diseases. Yoshida, A. Alcohol Alcohol. (1994) [Pubmed]
  6. Mammalian alcohol dehydrogenase - functional and structural implications. Höög, J.O., Hedberg, J.J., Strömberg, P., Svensson, S. J. Biomed. Sci. (2001) [Pubmed]
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