The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

ADH6  -  alcohol dehydrogenase 6 (class V)

Homo sapiens

Synonyms: ADH-5, Alcohol dehydrogenase 6
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on ADH6

  • The data lead to the clear conclusion that a combination of the alcohol dehydrogenase 6 (ADH6) basal promoter linked to two tandem copies of an apoplipoprotein E enhancer element is the transcriptional control unit of choice for the liver-specific expression of transgenes [1].
  • The sigma-ADH exhibited 75%, 68%, and 62% sequence identity to the human class I (beta 1), II (pi), and III (chi) isoenzymes, respectively, and 61% identity to the deduced ADH6 amino acid sequence [2].
  • The full-length ADH6 cDNA was expressed in the E.coli expression system and in the in vitro translation system of rabbit reticulocytes [3].
  • The human ADH5 and rodent ADH6 seem to be the corresponding enzymes due to their similar behavior [4].
  • The newly identified ADH6 gene has hormone response elements, and it may cause the gender difference in alcoholic problems [5].

Other interactions of ADH6

  • The higher classes, ADH5 and ADH6, have been poorly investigated and their substrate repertoire is unknown [6].


  1. Chimeric transcriptional control units for improved liver-specific transgene expression. Gehrke, S., Jérôme, V., Müller, R. Gene (2003) [Pubmed]
  2. Purification and partial amino acid sequence of a high-activity human stomach alcohol dehydrogenase. Stone, C.L., Thomasson, H.R., Bosron, W.F., Li, T.K. Alcohol. Clin. Exp. Res. (1993) [Pubmed]
  3. Enzymatic properties of the protein encoded by newly cloned human alcohol dehydrogenase ADH6 gene. Chen, C.S., Yoshida, A. Biochem. Biophys. Res. Commun. (1991) [Pubmed]
  4. The mammalian alcohol dehydrogenases interact in several metabolic pathways. Höög, J.O., Strömberg, P., Hedberg, J.J., Griffiths, W.J. Chem. Biol. Interact. (2003) [Pubmed]
  5. Genetic polymorphisms of alcohol metabolizing enzymes related to alcohol sensitivity and alcoholic diseases. Yoshida, A. Alcohol Alcohol. (1994) [Pubmed]
  6. Mammalian alcohol dehydrogenase - functional and structural implications. Höög, J.O., Hedberg, J.J., Strömberg, P., Svensson, S. J. Biomed. Sci. (2001) [Pubmed]
WikiGenes - Universities