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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Cyp4a14  -  cytochrome P450, family 4, subfamily a,...

Mus musculus

Synonyms: AI314743, CYPIVA14, Cytochrome P450 4A14, Cytochrome P450-LA-omega 3, Lauric acid omega-hydroxylase 3
 
 
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High impact information on Cyp4a14

  • Wy-14,643 prevented hepatic lipoperoxides from accumulating despite an 18-fold increase in both Cyp4a10 and Cyp4a14 mRNA [1].
  • Expression of the fatty acid omega-hydroxylase gene Cyp4a14, a commonly used indicator gene for Pparalpha activation, was strongly induced in wild-type mice after hepatectomy, suggesting that altered hepatocyte lipid processing may also contribute to the impaired regeneration in mice lacking the Pparalpha gene [2].
  • The Cyp4a14 gene spans approximately 13 kb, and contains 12 exons; sequence similarity to the rat CYP4A2 gene sequence falls off 300 bp upstream from the start site [3].

References

  1. Central role of PPARalpha-dependent hepatic lipid turnover in dietary steatohepatitis in mice. Ip, E., Farrell, G.C., Robertson, G., Hall, P., Kirsch, R., Leclercq, I. Hepatology (2003) [Pubmed]
  2. Delayed liver regeneration in peroxisome proliferator-activated receptor-alpha-null mice. Anderson, S.P., Yoon, L., Richard, E.B., Dunn, C.S., Cattley, R.C., Corton, J.C. Hepatology (2002) [Pubmed]
  3. A novel murine P-450 gene, Cyp4a14, is part of a cluster of Cyp4a and Cyp4b, but not of CYP4F, genes in mouse and humans. Heng, Y.M., Kuo, C.S., Jones, P.S., Savory, R., Schulz, R.M., Tomlinson, S.R., Gray, T.J., Bell, D.R. Biochem. J. (1997) [Pubmed]
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