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Gene Review

Cyp4a10  -  cytochrome P450, family 4, subfamily a,...

Mus musculus

Synonyms: AI647584, CYPIVA10, Cyp4a, Cyp4a-10, Cytochrome P450 4A10, ...
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Disease relevance of Cyp4a10

  • We show here that disruption of the murine cytochrome P450, family 4, subfamily a, polypeptide 10 (Cyp4a10) gene causes a type of hypertension that is, like most human hypertension, dietary salt sensitive [1].

High impact information on Cyp4a10

  • SH was associated with reduced cytochrome P450 (Cyp)2e1 but increased Cyp4a [2].
  • Wy-14,643 prevented hepatic lipoperoxides from accumulating despite an 18-fold increase in both Cyp4a10 and Cyp4a14 mRNA [3].
  • In conclusion, PPARalpha activation both increases Cyp4a expression and enhances hepatic lipid turnover; the latter effect removes fatty acids as substrate for lipid peroxidation and is sufficiently powerful to prevent the development of dietary steatohepatitis [3].
  • Cytochrome P450 4a (Cyp4a) and Cyp2e1 are potential hepatic sources of ROS [3].
  • Murine Cyp4a clones showed high sequence identity with members of the rat gene family, but CYP4A clones from human and guinea pig were equally similar to the rat/mouse genes, suggesting that the rat/mouse line had undergone gene duplication events after divergence from human and guinea-pig lines [4].

Biological context of Cyp4a10


Anatomical context of Cyp4a10


Associations of Cyp4a10 with chemical compounds

  • In addition, NO-1886 dampened hepatic steatosis via accelerating fatty acid oxidation caused by enhanced expression of PPARalpha, cytochrome P450-10 (Cyp4a10), and Acyl-CoA oxidase (ACO) [9].
  • The administration of phenobarbital and dexamethasone affected the expression of Cyp4a proteins in the liver, but not in the kidney, where testosterone was the key regulatory factor, demonstrating interesting tissue-specific effects in the regulation of these enzymes [10].
  • Treatment with DOCA-salt resulted in significantly decreased hydroxylase activities (to 84+/-4 pmol. min(-1). mg(-1)) of the total microsomal P450 content and a decrease in immunodetectable Cyp4a proteins [11].

Other interactions of Cyp4a10


Analytical, diagnostic and therapeutic context of Cyp4a10


  1. Salt-sensitive hypertension is associated with dysfunctional Cyp4a10 gene and kidney epithelial sodium channel. Nakagawa, K., Holla, V.R., Wei, Y., Wang, W.H., Gatica, A., Wei, S., Mei, S., Miller, C.M., Cha, D.R., Price, E., Zent, R., Pozzi, A., Breyer, M.D., Guan, Y., Falck, J.R., Waterman, M.R., Capdevila, J.H. J. Clin. Invest. (2006) [Pubmed]
  2. Steatohepatitis induced by intragastric overfeeding in mice. Deng, Q.G., She, H., Cheng, J.H., French, S.W., Koop, D.R., Xiong, S., Tsukamoto, H. Hepatology (2005) [Pubmed]
  3. Central role of PPARalpha-dependent hepatic lipid turnover in dietary steatohepatitis in mice. Ip, E., Farrell, G.C., Robertson, G., Hall, P., Kirsch, R., Leclercq, I. Hepatology (2003) [Pubmed]
  4. Species-specific induction of cytochrome P-450 4A RNAs: PCR cloning of partial guinea-pig, human and mouse CYP4A cDNAs. Bell, D.R., Plant, N.J., Rider, C.G., Na, L., Brown, S., Ateitalla, I., Acharya, S.K., Davies, M.H., Elias, E., Jenkins, N.A. Biochem. J. (1993) [Pubmed]
  5. Expression of cytochrome P450 4A mRNA in mouse lung: effect of clofibrate and interleukin-1beta. Le Bouquin, R., Lugnier, A., Frossard, N., Pons, F. Fundamental & clinical pharmacology. (2004) [Pubmed]
  6. Induction of CYP3A expression by dehydroepiandrosterone: involvement of the pregnane X receptor. Ripp, S.L., Fitzpatrick, J.L., Peters, J.M., Prough, R.A. Drug Metab. Dispos. (2002) [Pubmed]
  7. Mapping of the azh locus to mouse chromosome 4. Meistrich, M.L., Trostle-Weige, P.K., Womack, J.E. J. Hered. (1992) [Pubmed]
  8. Activities of cytochrome p450 enzymes in liver and kidney microsomes from systemic carnitine deficiency mice with a gene mutation of carnitine/organic cation transporter. Yamazaki, H., Iketaki, H., Shibata, A., Nakajima, M., Yokoi, T. Drug Metab. Pharmacokinet. (2002) [Pubmed]
  9. Lipoprotein lipase activator ameliorates the severity of dietary steatohepatitis. Yu, J., Chu, E.S., Hui, A.Y., Cheung, K.F., Chan, H.L., Leung, W.K., Farrell, G.C., Sung, J.J. Biochem. Biophys. Res. Commun. (2007) [Pubmed]
  10. Deduced amino acid sequence of a murine cytochrome P-450 Cyp4a protein: developmental and hormonal regulation in liver and kidney. Henderson, C.J., Bammler, T., Wolf, C.R. Biochim. Biophys. Acta (1994) [Pubmed]
  11. Cytochrome P450-dependent renal arachidonic acid metabolism in desoxycorticosterone acetate-salt hypertensive mice. Honeck, H., Gross, V., Erdmann, B., Kärgel, E., Neunaber, R., Milia, A.F., Schneider, W., Luft, F.C., Schunck, W.H. Hypertension (2000) [Pubmed]
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