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Gene Review

COX6A2  -  cytochrome c oxidase subunit VIa...

Homo sapiens

Synonyms: COX VIa-M, COX6A, COX6AH, COXVIAH, Cytochrome c oxidase polypeptide VIa-heart, ...
 
 
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High impact information on COX6A2

  • Nonsynonymous (amino acid replacement) substitutions in the COX6AH gene occurred more frequently than in the ubiquitously expressed COX6AL gene [1].
  • Structure of the human gene (COX6A2) for the heart/muscle isoform of cytochrome c oxidase subunit VIa and its chromosomal location in humans, mice, and cattle [2].
  • From the regions of known gene conservation among these three species, we predicted that human COX6AH would be located on chromosome 16p [2].
  • The sequences of the proximal 5' flanking regions of COX6AH genes are highly conserved between human, bovine, and rodent [2].
  • The human COX6AH gene spans about 1 kb and contains three exons and two small introns [2].

References

  1. Molecular evolution of cytochrome c oxidase: rate variation among subunit VIa isoforms. Schmidt, T.R., Jaradat, S.A., Goodman, M., Lomax, M.I., Grossman, L.I. Mol. Biol. Evol. (1997) [Pubmed]
  2. Structure of the human gene (COX6A2) for the heart/muscle isoform of cytochrome c oxidase subunit VIa and its chromosomal location in humans, mice, and cattle. Bachman, N.J., Riggs, P.K., Siddiqui, N., Makris, G.J., Womack, J.E., Lomax, M.I. Genomics (1997) [Pubmed]
 
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