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Gene Review

COX6A1  -  cytochrome c oxidase subunit VIa...

Homo sapiens

Synonyms: CMTRID, COX VIa-L, COX6A, COX6AL, Cytochrome c oxidase polypeptide VIa-liver, ...
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High impact information on COX6A1

  • Nonsynonymous (amino acid replacement) substitutions in the COX6AH gene occurred more frequently than in the ubiquitously expressed COX6AL gene [1].
  • Monocular impulse blockade in adult monkeys induced a downregulation of COX6A1 expression in deprived visual neurons, suggesting that this subunit gene is regulated by neuronal activity [2].
  • COX6A1 cDNA was isolated from a human brain cDNA library, and the sequence was identical to that of human liver [2].
  • 2. We compared the COX6A1 gene with the published cDNA and several ESTs and concluded that subunit COX VIa-L is synthesized as a preprotein, as are other COX subunits [2].
  • Assignment of COX6A1 to 6p21 and a pseudogene (COX6A1P) to 1p31.1 by in situ hybridization and somatic cell hybrids [3].


  1. Molecular evolution of cytochrome c oxidase: rate variation among subunit VIa isoforms. Schmidt, T.R., Jaradat, S.A., Goodman, M., Lomax, M.I., Grossman, L.I. Mol. Biol. Evol. (1997) [Pubmed]
  2. Human COX6A1 gene: promoter analysis, cDNA isolation and expression in the monkey brain. Wong-Riley, M., Guo, A., Bachman, N.J., Lomax, M.I. Gene (2000) [Pubmed]
  3. Assignment of COX6A1 to 6p21 and a pseudogene (COX6A1P) to 1p31.1 by in situ hybridization and somatic cell hybrids. Hey, Y., Hoggard, N., Burt, E., James, L.A., Varley, J.M. Cytogenet. Cell Genet. (1997) [Pubmed]
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