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Gene Review:

polyprotein - polyprotein

Papaya leaf distortion mosaic virus

Waltermann, A. et al., Kelloniemi, J. et al., Gargouri-Bouzid, R. et al., Stenger, D.C. et al.

Gargouri-Bouzid, Jaoua, Rouis, Saídi, Bouaziz, Ellouz,

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Disease relevance of polyprotein

Nested deletion analysis of Wheat streak mosaic virus HC-Pro: Mapping of domains affecting polyprotein processing and eriophyid mite transmission [1].
The RNA genome of Plum pox virus (PPV) encodes one large polyprotein that is subsequently cleaved into mature viral proteins [2].
Potato virus A (PVA), a potyvirus with a (+)ssRNA genome translated to a large polyprotein, was engineered and used as a gene vector for expression of heterologous proteins in plants [3].

High impact information on polyprotein

The NIa protease forms the nuclear inclusion body A and acts as the major protease in the cleavage of the viral polyprotein into functional proteins [4].

References

Nested deletion analysis of Wheat streak mosaic virus HC-Pro: Mapping of domains affecting polyprotein processing and eriophyid mite transmission. Stenger, D.C., Hein, G.L., French, R. Virology (2006) [Pubmed]
Detection of 6K1 as a mature protein of 6 kDa in plum pox virus-infected Nicotiana benthamiana. Waltermann, A., Maiss, E. J. Gen. Virol. (2006) [Pubmed]
A potyvirus-based gene vector allows producing active human S-COMT and animal GFP, but not human sorcin, in vector-infected plants. Kelloniemi, J., Mäkinen, K., Valkonen, J.P. Biochimie (2006) [Pubmed]
PVY-Resistant Transgenic Potato Plants Expressing an Anti-NIa Protein scFv Antibody. Gargouri-Bouzid, R., Jaoua, L., Rouis, S., Saídi, M.N., Bouaziz, D., Ellouz, R. Mol. Biotechnol. (2006) [Pubmed]

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