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Gene Review:

Nploc4 - nuclear protein localization 4 homolog (S....

Rattus norvegicus

Synonyms: Npl4, Nuclear protein localization protein 4 homolog, Protein NPL4

Meyer, H.H. et al., Bruderer, R.M. et al., Wang, B. et al.

Meyer, Wang, Warren,

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High impact information on Nploc4

In the case of Ufd1-Npl4, which is involved in endoplasmic reticulum (ER)-associated degradation and nuclear envelope reassembly, binding to ubiquitin is mediated through a putative zinc finger in Npl4 [1].
The second binding site is located at the N terminus of Npl4 and is activated upon binding of Ufd1 to Npl4 [2].
Structure and ubiquitin interactions of the conserved zinc finger domain of Npl4 [3].

References

Direct binding of ubiquitin conjugates by the mammalian p97 adaptor complexes, p47 and Ufd1-Npl4. Meyer, H.H., Wang, Y., Warren, G. EMBO J. (2002) [Pubmed]
The AAA ATPase p97/VCP interacts with its alternative co-factors, Ufd1-Npl4 and p47, through a common bipartite binding mechanism. Bruderer, R.M., Brasseur, C., Meyer, H.H. J. Biol. Chem. (2004) [Pubmed]
Structure and ubiquitin interactions of the conserved zinc finger domain of Npl4. Wang, B., Alam, S.L., Meyer, H.H., Payne, M., Stemmler, T.L., Davis, D.R., Sundquist, W.I. J. Biol. Chem. (2003) [Pubmed]

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