Gene Review:
NPL4 - Npl4p
Saccharomyces cerevisiae S288c
Synonyms:
HMG-CoA reductase degradation protein 4, HRD4, Nuclear protein localization protein 4, YBR1231, YBR170C
- The AAA-ATPase Cdc48/p97 regulates spindle disassembly at the end of mitosis. Cao, K., Nakajima, R., Meyer, H.H., Zheng, Y. Cell (2003)
- Mobilization of processed, membrane-tethered SPT23 transcription factor by CDC48(UFD1/NPL4), a ubiquitin-selective chaperone. Rape, M., Hoppe, T., Gorr, I., Kalocay, M., Richly, H., Jentsch, S. Cell (2001)
- Distinct AAA-ATPase p97 complexes function in discrete steps of nuclear assembly. Hetzer, M., Meyer, H.H., Walther, T.C., Bilbao-Cortes, D., Warren, G., Mattaj, I.W. Nat. Cell Biol. (2001)
- Function of the p97-Ufd1-Npl4 complex in retrotranslocation from the ER to the cytosol: dual recognition of nonubiquitinated polypeptide segments and polyubiquitin chains. Ye, Y., Meyer, H.H., Rapoport, T.A. J. Cell Biol. (2003)
- Role of the ubiquitin-selective CDC48(UFD1/NPL4 )chaperone (segregase) in ERAD of OLE1 and other substrates. Braun, S., Matuschewski, K., Rape, M., Thoms, S., Jentsch, S. EMBO J. (2002)
- HRD4/NPL4 is required for the proteasomal processing of ubiquitinated ER proteins. Bays, N.W., Wilhovsky, S.K., Goradia, A., Hodgkiss-Harlow, K., Hampton, R.Y. Mol. Biol. Cell (2001)
- Cloning and characterization of the gene encoding human NPL4, a protein interacting with the ubiquitin fusion-degradation protein (UFD1L). Botta, A., Tandoi, C., Fini, G., Calabrese, G., Dallapiccola, B., Novelli, G. Gene (2001)
- The Cdc48/p97-Ufd1-Npl4 complex: its potential role in coordinating cellular morphogenesis during the M-G1 transition. Cao, K., Zheng, Y. Cell Cycle (2004)
- Nuclear transport defects and nuclear envelope alterations are associated with mutation of the Saccharomyces cerevisiae NPL4 gene. DeHoratius, C., Silver, P.A. Mol. Biol. Cell (1996)
- Rsp5p is required for ER bound Mga2p120 polyubiquitination and release of the processed/tethered transactivator Mga2p90. Shcherbik, N., Zoladek, T., Nickels, J.T., Haines, D.S. Curr. Biol. (2003)
- A subset of membrane-associated proteins is ubiquitinated in response to mutations in the endoplasmic reticulum degradation machinery. Hitchcock, A.L., Auld, K., Gygi, S.P., Silver, P.A. Proc. Natl. Acad. Sci. U.S.A. (2003)
- The Conserved ATPase Get3/Arr4 Modulates the Activity of Membrane-Associated Proteins in Saccharomyces cerevisiae. Auld, K.L., Hitchcock, A.L., Doherty, H.K., Frietze, S., Huang, L.S., Silver, P.A. Genetics (2006)
- Cdc48-Ufd1-Npl4: stuck in the middle with Ub. Bays, N.W., Hampton, R.Y. Curr. Biol. (2002)