The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

CRYGC  -  crystallin, gamma C

Homo sapiens

Synonyms: CCL, CRYG3, CTRCT2, Gamma-C-crystallin, Gamma-crystallin 2-1, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of CRYGC

  • The current study extends those findings to the following crystallin genes involved in some congenital cataracts: CRYAA (R116C), CRYAB (R120G), and CRYGC (T5P) [1].

High impact information on CRYGC

  • To our knowledge, these findings are the first evidence of an involvement of CRYGC and support the role of CRYGD in human cataract formation [2].
  • Further analysis of the original Coppock-like-cataract family identified a missense mutation in a highly conserved segment of exon 2 of CRYGC [2].
  • This diastereomeric mixture was resolved by enzymatic acetylation with CCL [3].
  • CRYGC (T5P) is one of the many gamma-crystallin mutant genes for autosomal dominant congenital cataracts [4].

Biological context of CRYGC

  • A functional candidate gene approach was employed for PCR screening and sequencing of the exons and their flanking regions of CRYGC, CRYGD, and CRYAA genes [5].

Analytical, diagnostic and therapeutic context of CRYGC


  1. Alteration of protein-protein interactions of congenital cataract crystallin mutants. Fu, L., Liang, J.J. Invest. Ophthalmol. Vis. Sci. (2003) [Pubmed]
  2. The gamma-crystallins and human cataracts: a puzzle made clearer. Héon, E., Priston, M., Schorderet, D.F., Billingsley, G.D., Girard, P.O., Lubsen, N., Munier, F.L. Am. J. Hum. Genet. (1999) [Pubmed]
  3. Seven-membered cyclic sulfite eudesmane derivatives: partial synthesis, structural determination, and enzymatic resolution. García-Granados, A., Parra, A., Rivas, F., Segovia, A.J. J. Org. Chem. (2007) [Pubmed]
  4. Conformational change and destabilization of cataract gammaC-crystallin T5P mutant. Fu, L., Liang, J.J. FEBS Lett. (2002) [Pubmed]
  5. Identification of a novel, putative cataract-causing allele in CRYAA (G98R) in an Indian family. Santhiya, S.T., Soker, T., Klopp, N., Illig, T., Prakash, M.V., Selvaraj, B., Gopinath, P.M., Graw, J. Mol. Vis. (2006) [Pubmed]
WikiGenes - Universities