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Gene Review

Fhl3  -  four and a half LIM domains 3

Mus musculus

Synonyms: FHL-3, Four and a half LIM domains protein 3, SLIM-2, Skeletal muscle LIM-protein 2
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High impact information on Fhl3

  • However, in cardiac and skeletal muscles, FHL2 and FHL3, respectively, are colocalized with alpha(7)beta(1) integrin receptor at the periphery of Z-discs, suggesting a role in mechanical stabilization of muscle cells [1].

Biological context of Fhl3

  • FHL1 and FHL3 mRNAs were reciprocally expressed in the murine C2C12 skeletal muscle cell line and this suggested that the pattern of expression was linked to key events in myogenesis [2].


  1. The LIM-only proteins FHL2 and FHL3 interact with alpha- and beta-subunits of the muscle alpha7beta1 integrin receptor. Samson, T., Smyth, N., Janetzky, S., Wendler, O., Müller, J.M., Schüle, R., von der Mark, H., von der Mark, K., Wixler, V. J. Biol. Chem. (2004) [Pubmed]
  2. The LIM proteins FHL1 and FHL3 are expressed differently in skeletal muscle. Morgan, M.J., Madgwick, A.J. Biochem. Biophys. Res. Commun. (1999) [Pubmed]
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