Chemical Compound Review:
Integrin 5,6-dimethoxy-2-methyl-3-[2- (4...
Synonyms:
Opertil, Oxipertina, Oxipertine, oxypertine, Equipertine, ...
Sethi,
MacKinnon,
Salter,
Strieter,
Dransfield,
Moore,
Rintoul,
Donnelly,
Chilvers,
Choo,
Haslett,
Hermiston,
Xu,
Weiss,
Levite,
Cahalon,
Desai,
Hershkoviz,
Sobko,
Lider,
Ariel,
Peretz,
Attali,
Geiger,
Luo,
Springer,
Carman,
Mayer,
Fässler,
von der Mark,
Echtermeyer,
von der Mark,
Bornemann,
Miosge,
Saher,
Pöschl,
Pribila,
Quale,
Mueller,
Shimizu,
Alexandre Chigaev,
Liliana Halip,
Anna Waller,
Cristian G. Bologa,
Larry A. Sklar,
Or Amit,
Chavis,
Westbrook,
Sheppard,
- Beta 4 integrin amplifies ErbB2 signaling to promote mammary tumorigenesis. Guo, W., Pylayeva, Y., Pepe, A., Yoshioka, T., Muller, W.J., Inghirami, G., Giancotti, F.G. Cell (2006)
- Integrins alpha v beta 3 and alpha v beta 5 promote adenovirus internalization but not virus attachment. Wickham, T.J., Mathias, P., Cheresh, D.A., Nemerow, G.R. Cell (1993)
- A hybrid vector for ligand-directed tumor targeting and molecular imaging. Hajitou, A., Trepel, M., Lilley, C.E., Soghomonyan, S., Alauddin, M.M., Marini, F.C., Restel, B.H., Ozawa, M.G., Moya, C.A., Rangel, R., Sun, Y., Zaoui, K., Schmidt, M., von Kalle, C., Weitzman, M.D., Gelovani, J.G., Pasqualini, R., Arap, W. Cell (2006)
- Mutations in the integrin alpha7 gene cause congenital myopathy. Hayashi, Y.K., Chou, F.L., Engvall, E., Ogawa, M., Matsuda, C., Hirabayashi, S., Yokochi, K., Ziober, B.L., Kramer, R.H., Kaufman, S.J., Ozawa, E., Goto, Y., Nonaka, I., Tsukahara, T., Wang, J.Z., Hoffman, E.P., Arahata, K. Nat. Genet. (1998)
- Suprabasal integrin expression in the epidermis of transgenic mice results in developmental defects and a phenotype resembling psoriasis. Carroll, J.M., Romero, M.R., Watt, F.M. Cell (1995)
- Src tyrosine kinases mediate activations of NF-kappaB and integrin signal during lipopolysaccharide-induced acute lung injury. Lee, H.S., Moon, C., Lee, H.W., Park, E.M., Cho, M.S., Kang, J.L. J. Immunol. (2007)
- Aberrant activation of integrin alpha4beta7 suppresses lymphocyte migration to the gut. Park, E.J., Mora, J.R., Carman, C.V., Chen, J., Sasaki, Y., Cheng, G., von Andrian, U.H., Shimaoka, M. J. Clin. Invest. (2007)
- Identification of Pur alpha as a new hypoxia response factor responsible for coordinated induction of the beta 2 integrin family. Kong, T., Scully, M., Shelley, C.S., Colgan, S.P. J. Immunol. (2007)
- Prostate cancer specific integrin alphavbeta3 modulates bone metastatic growth and tissue remodeling. McCabe, N.P., De, S., Vasanji, A., Brainard, J., Byzova, T.V. Oncogene (2007)
- Proapoptotic function of integrin beta(3) in human hepatocellular carcinoma cells. Wu, Y., Zuo, J., Ji, G., Saiyin, H., Liu, X., Yin, F., Cao, N., Wen, Y., Li, J.J., Yu, L. Clin. Cancer Res. (2009)
- The pivotal role of integrin β1 in metastasis of head and neck squamous cell carcinoma. Wang, D., Müller, S., Amin, A.R., Huang, D., Su, L., Hu, Z., Rahman, M.A., Nannapaneni, S., Koenig, L., Chen, Z., Tighiouart, M., Shin, D.M., Chen, Z.G. Clin. Cancer Res. (2012)
- Integrin-mediated short-term memory in Drosophila. Grotewiel, M.S., Beck, C.D., Wu, K.H., Zhu, X.R., Davis, R.L. Nature (1998)
- Extracellular K(+) and opening of voltage-gated potassium channels activate T cell integrin function: physical and functional association between Kv1.3 channels and beta1 integrins. Levite, M., Cahalon, L., Peretz, A., Hershkoviz, R., Sobko, A., Ariel, A., Desai, R., Attali, B., Lider, O. J. Exp. Med. (2000)
- The alpha5beta1 integrin mediates elimination of amyloid-beta peptide and protects against apoptosis. Matter, M.L., Zhang, Z., Nordstedt, C., Ruoslahti, E. J. Cell Biol. (1998)
- Interaction of West Nile virus with alpha v beta 3 integrin mediates virus entry into cells. Chu, J.J., Ng, M.L. J. Biol. Chem. (2004)
- Constitutive and induced phosphorylation of the alpha- and beta-chains of the CD11/CD18 leukocyte integrin family. Relationship to adhesion-dependent functions. Buyon, J.P., Slade, S.G., Reibman, J., Abramson, S.B., Philips, M.R., Weissmann, G., Winchester, R. J. Immunol. (1990)
- Structural basis of integrin regulation and signaling. Luo, B.H., Carman, C.V., Springer, T.A. Annu. Rev. Immunol. (2007)
- Integrins and T cell-mediated immunity. Pribila, J.T., Quale, A.C., Mueller, K.L., Shimizu, Y. Annu. Rev. Immunol. (2004)
- CD45: a critical regulator of signaling thresholds in immune cells. Hermiston, M.L., Xu, Z., Weiss, A. Annu. Rev. Immunol. (2003)
- VLA proteins in the integrin family: structures, functions, and their role on leukocytes. Hemler, M.E. Annu. Rev. Immunol. (1990)
- Paxillin: adapting to change. Brown, M.C., Turner, C.E. Physiol. Rev. (2004)
- A discrete sequence in a platelet integrin is involved in ligand recognition. D'Souza, S.E., Ginsberg, M.H., Matsueda, G.R., Plow, E.F. Nature (1991)
- Structure of a major immunogenic site on foot-and-mouth disease virus. Logan, D., Abu-Ghazaleh, R., Blakemore, W., Curry, S., Jackson, T., King, A., Lea, S., Lewis, R., Newman, J., Parry, N. Nature (1993)
- AlphaVbeta5 integrin: a co-receptor for adeno-associated virus type 2 infection. Summerford, C., Bartlett, J.S., Samulski, R.J. Nat. Med. (1999)
- Mac-1 signaling via Src-family and Syk kinases results in elastase-dependent thrombohemorrhagic vasculopathy. Hirahashi, J., Mekala, D., Van Ziffle, J., Xiao, L., Saffaripour, S., Wagner, D.D., Shapiro, S.D., Lowell, C., Mayadas, T.N. Immunity (2006)
- Blockade of attachment and fusion receptors inhibits HIV-1 infection of human cervical tissue. Hu, Q., Frank, I., Williams, V., Santos, J.J., Watts, P., Griffin, G.E., Moore, J.P., Pope, M., Shattock, R.J. J. Exp. Med. (2004)
- Multiple beta 1 chain integrins are receptors for invasin, a protein that promotes bacterial penetration into mammalian cells. Isberg, R.R., Leong, J.M. Cell (1990)
- A Role for p130Cas in Mechanotransduction. Geiger, B. Cell (2006)
- Integrin alpha v beta 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels. Brooks, P.C., Montgomery, A.M., Rosenfeld, M., Reisfeld, R.A., Hu, T., Klier, G., Cheresh, D.A. Cell (1994)
- Fibrillar collagen inhibits arterial smooth muscle proliferation through regulation of Cdk2 inhibitors. Koyama, H., Raines, E.W., Bornfeldt, K.E., Roberts, J.M., Ross, R. Cell (1996)
- Functions of pulmonary epithelial integrins: from development to disease. Sheppard, D. Physiol. Rev. (2003)
- Recognition of distinct adhesive sites on fibrinogen by related integrins on platelets and endothelial cells. Cheresh, D.A., Berliner, S.A., Vicente, V., Ruggeri, Z.M. Cell (1989)
- Integrin alpha 2 beta 1 (VLA-2) mediates reorganization and contraction of collagen matrices by human cells. Schiro, J.A., Chan, B.M., Roswit, W.T., Kassner, P.D., Pentland, A.P., Hemler, M.E., Eisen, A.Z., Kupper, T.S. Cell (1991)
- Tenascin interferes with fibronectin action. Chiquet-Ehrismann, R., Kalla, P., Pearson, C.A., Beck, K., Chiquet, M. Cell (1988)
- p120-Catenin and p190RhoGAP Regulate Cell-Cell Adhesion by Coordinating Antagonism between Rac and Rho. Wildenberg, G.A., Dohn, M.R., Carnahan, R.H., Davis, M.A., Lobdell, N.A., Settleman, J., Reynolds, A.B. Cell (2006)
- Structure of integrin, a glycoprotein involved in the transmembrane linkage between fibronectin and actin. Tamkun, J.W., DeSimone, D.W., Fonda, D., Patel, R.S., Buck, C., Horwitz, A.F., Hynes, R.O. Cell (1986)
- Recognition of a bacterial adhesion by an integrin: macrophage CR3 (alpha M beta 2, CD11b/CD18) binds filamentous hemagglutinin of Bordetella pertussis. Relman, D., Tuomanen, E., Falkow, S., Golenbock, D.T., Saukkonen, K., Wright, S.D. Cell (1990)
- Integrins mediate functional pre- and postsynaptic maturation at a hippocampal synapse. Chavis, P., Westbrook, G. Nature (2001)
- (64)Cu-labeled tetrameric and octameric RGD peptides for small-animal PET of tumor alpha(v)beta(3) integrin expression. Li, Z.B., Cai, W., Cao, Q., Chen, K., Wu, Z., He, L., Chen, X. J. Nucl. Med. (2007)
- Fer-mediated cortactin phosphorylation is associated with efficient fibroblast migration and is dependent on reactive oxygen species generation during integrin-mediated cell adhesion. Sangrar, W., Gao, Y., Scott, M., Truesdell, P., Greer, P.A. Mol. Cell. Biol. (2007)
- Role of the beta-subunit arginine/lysine finger in integrin heterodimer formation and function. Gupta, V., Alonso, J.L., Sugimori, T., Essafi, M., Issafi, M., Xiong, J.P., Arnaout, M.A. J. Immunol. (2008)
- Real-time analysis of conformation-sensitive antibody binding provides new insights into integrin conformational regulation. Chigaev, A., Waller, A., Amit, O., Halip, L., Bologa, C.G., Sklar, L.A. J. Biol. Chem. (2009)
- Glucocorticoids increase alpha5 integrin expression and adhesion of synovial fibroblasts but inhibit ERK signaling, migration, and cartilage invasion. Lowin, T., Straub, R.H., Neumann, E., Bosserhoff, A., Vogel, C., Moissl, C., Anders, S., Müller-Ladner, U., Schedel, J. Arthritis Rheum. (2009)
- Pharmacokinetically Stabilized Cystine Knot Peptides That Bind Alpha-v-Beta-6 Integrin with Single-Digit Nanomolar Affinities for Detection of Pancreatic Cancer. Kimura, R.H., Teed, R., Hackel, B.J., Pysz, M.A., Chuang, C.Z., Sathirachinda, A., Willmann, J.K., Gambhir, S.S. Clin. Cancer Res. (2012)
- Alpha L beta 2 integrin/LFA-1 binding to ICAM-1 induced by cytohesin-1, a cytoplasmic regulatory molecule. Kolanus, W., Nagel, W., Schiller, B., Zeitlmann, L., Godar, S., Stockinger, H., Seed, B. Cell (1996)
- Absence of integrin alpha 7 causes a novel form of muscular dystrophy. Mayer, U., Saher, G., Fässler, R., Bornemann, A., Echtermeyer, F., von der Mark, H., Miosge, N., Pöschl, E., von der Mark, K. Nat. Genet. (1997)
- Mutations in the 180-kD bullous pemphigoid antigen (BPAG2), a hemidesmosomal transmembrane collagen (COL17A1), in generalized atrophic benign epidermolysis bullosa. McGrath, J.A., Gatalica, B., Christiano, A.M., Li, K., Owaribe, K., McMillan, J.R., Eady, R.A., Uitto, J. Nat. Genet. (1995)
- TIMP-2 mediated inhibition of angiogenesis: an MMP-independent mechanism. Seo, D.W., Li, H., Guedez, L., Wingfield, P.T., Diaz, T., Salloum, R., Wei, B.Y., Stetler-Stevenson, W.G. Cell (2003)
- Endothelial Lu/BCAM glycoproteins are novel ligands for red blood cell alpha4beta1 integrin: role in adhesion of sickle red blood cells to endothelial cells. El Nemer, W., Wautier, M.P., Rahuel, C., Gane, P., Hermand, P., Galactéros, F., Wautier, J.L., Cartron, J.P., Colin, Y., Le Van Kim, C. Blood (2007)
- Numb controls integrin endocytosis for directional cell migration with aPKC and PAR-3. Nishimura, T., Kaibuchi, K. Dev. Cell (2007)
- Activation signal transduction by beta1 integrin in T cells from patients with systemic lupus erythematosus. Nakayamada, S., Saito, K., Nakano, K., Tanaka, Y. Arthritis Rheum. (2007)
- Crosstalk between the alpha2beta1 integrin and c-met/HGF-R regulates innate immunity. McCall-Culbreath, K.D., Li, Z., Zutter, M.M. Blood (2008)
- Integrin alpha9beta1 mediates enhanced cell migration through nitric oxide synthase activity regulated by Src tyrosine kinase. Gupta, S.K., Vlahakis, N.E. J. Cell. Sci. (2009)
- Beta8 integrin regulates neurogenesis and neurovascular homeostasis in the adult brain. Mobley, A.K., Tchaicha, J.H., Shin, J., Hossain, M.G., McCarty, J.H. J. Cell. Sci. (2009)
- Coordinate integrin and c-Met signaling regulate Wnt gene expression during epithelial morphogenesis. Liu, Y., Chattopadhyay, N., Qin, S., Szekeres, C., Vasylyeva, T., Mahoney, Z.X., Taglienti, M., Bates, C.M., Chapman, H.A., Miner, J.H., Kreidberg, J.A. Development (2009)
- The adaptor protein Shc couples a class of integrins to the control of cell cycle progression. Wary, K.K., Mainiero, F., Isakoff, S.J., Marcantonio, E.E., Giancotti, F.G. Cell (1996)
- Extracellular matrix proteins protect small cell lung cancer cells against apoptosis: a mechanism for small cell lung cancer growth and drug resistance in vivo. Sethi, T., Rintoul, R.C., Moore, S.M., MacKinnon, A.C., Salter, D., Choo, C., Chilvers, E.R., Dransfield, I., Donnelly, S.C., Strieter, R., Haslett, C. Nat. Med. (1999)
- Fibronectin and VLA-4 in haematopoietic stem cell-microenvironment interactions. Williams, D.A., Rios, M., Stephens, C., Patel, V.P. Nature (1991)
- Integrin regulation of lymphocyte trafficking: lessons from structural and signaling studies. Kinashi, T. Adv. Immunol. (2007)