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Gene Review:

atzE - biuret hydrolase

Pseudomonas sp. ADP

Martinez, B. et al., Shapir, N. et al.

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Disease relevance of atzE

E. coli strains bearing atzE and atzF were shown to encode a biuret hydrolase and allophanate hydrolase, respectively. atzDEF are cotranscribed [1].

High impact information on atzE

Since biuret and allophanate are consecutive metabolites in cyanuric acid metabolism, the low level of biuret hydrolase activity can have physiological significance [2].
Functional analyses identified three new catabolic genes, atzD, atzE, and atzF, which participate in atrazine catabolism [1].
Two other genes encoding the further catabolism of cyanuric acid, atzE and atzF, reside in a contiguous cluster adjacent to a potential LysR-type transcriptional regulator [1].

References

Complete nucleotide sequence and organization of the atrazine catabolic plasmid pADP-1 from Pseudomonas sp. strain ADP. Martinez, B., Tomkins, J., Wackett, L.P., Wing, R., Sadowsky, M.J. J. Bacteriol. (2001) [Pubmed]
Purification and characterization of TrzF: biuret hydrolysis by allophanate hydrolase supports growth. Shapir, N., Cheng, G., Sadowsky, M.J., Wackett, L.P. Appl. Environ. Microbiol. (2006) [Pubmed]

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