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Gene Review

Rabac1  -  Rab acceptor 1 (prenylated)

Mus musculus

Synonyms: 2310040I06Rik, Gbpap1, PRA1, PRA1 family protein 1, Pra, ...
 
 
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High impact information on Rabac1

  • The interaction of these small GTPases with PRA1 requires their post-translational modification by prenylation [1].
  • The amino acid sequence of the protein portion of mp58 as deduced from the DNA sequence of its encoding gene (FBP1/PRA1) was used to synthesize a complete set of overlapping dodecapeptides (overlap, 7; offset, 5) covalently attached to the surface of derivatized polyethylene pins [2].
  • However, deletion of Val185 has only moderate effect on the ER export of prenylin, suggesting that this valine residue is not part of an export signal itself; instead, it may affect the folding and conformation of prenylin [3].
  • This region contains a di-acidic motif (Asp176-Xaa-Glu), but changing either acidic residue to alanine has no effect on the ER export of prenylin [3].
  • Thus we have identified a single C-terminal valine residue that is essential for the proper dimerization and ER export of prenylin [3].
 

Biological context of Rabac1

  • Alanine-scanning mutagenesis of the entire C-terminal region reveals that only the very C-terminal Val185 residue is crucial for the ER export of prenylin [3].
 

Anatomical context of Rabac1

 

Analytical, diagnostic and therapeutic context of Rabac1

References

 
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